GDI0147 protein (Gluconacetobacter diazotrophicus)

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white nodes:
second shell of interactors

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a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

GDI0147

Putative Acyl-protein thioesterase 1. (222 aa)

Predicted Functional Partners:

GDI0146

0.548

GDI1784

0.508

GDI0283

0.466

GDI3361

0.466

GDI0950

0.458

dnaK

0.450

dnaK-2

0.450

GDI3757

0.449

GDI1332

0.439

Your Current Organism:

Gluconacetobacter diazotrophicus

NCBI taxonomy Id: 272568
Other names: G. diazotrophicus PA1 5, Gluconacetobacter diazotrophicus ATCC 49037, Gluconacetobacter diazotrophicus BR 11281, Gluconacetobacter diazotrophicus CCUG 37298, Gluconacetobacter diazotrophicus CIP 103539, Gluconacetobacter diazotrophicus DSM 5601, Gluconacetobacter diazotrophicus LMG 7603, Gluconacetobacter diazotrophicus NCCB 89154, Gluconacetobacter diazotrophicus PA1 5, Gluconacetobacter diazotrophicus str. PA1 5, Gluconacetobacter diazotrophicus strain PA1 5

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GDI0146	GDI0147	GDI0146	GDI0147	Putative polyketide synthase.	Putative Acyl-protein thioesterase 1.	0.548
GDI0147	GDI0146	GDI0147	GDI0146	Putative Acyl-protein thioesterase 1.	Putative polyketide synthase.	0.548
GDI0147	GDI0283	GDI0147	GDI0283	Putative Acyl-protein thioesterase 1.	Conserved protein.	0.466
GDI0147	GDI0950	GDI0147	GDI0950	Putative Acyl-protein thioesterase 1.	Putative patatin-like phospholipase.	0.458
GDI0147	GDI1332	GDI0147	GDI1332	Putative Acyl-protein thioesterase 1.	Peptidase protein.	0.439
GDI0147	GDI1784	GDI0147	GDI1784	Putative Acyl-protein thioesterase 1.	Putative Na+/H+ antiporter.	0.508
GDI0147	GDI3361	GDI0147	GDI3361	Putative Acyl-protein thioesterase 1.	Hypothetical protein.	0.466
GDI0147	GDI3757	GDI0147	GDI3757	Putative Acyl-protein thioesterase 1.	Putative glycerophosphoryl diester phosphodiesterase.	0.449
GDI0147	dnaK	GDI0147	GDI0818	Putative Acyl-protein thioesterase 1.	Putative chaperone protein dnaK.	0.450
GDI0147	dnaK-2	GDI0147	GDI1262	Putative Acyl-protein thioesterase 1.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.450
GDI0283	GDI0147	GDI0283	GDI0147	Conserved protein.	Putative Acyl-protein thioesterase 1.	0.466
GDI0283	GDI0950	GDI0283	GDI0950	Conserved protein.	Putative patatin-like phospholipase.	0.443
GDI0283	GDI1784	GDI0283	GDI1784	Conserved protein.	Putative Na+/H+ antiporter.	0.776
GDI0283	GDI3757	GDI0283	GDI3757	Conserved protein.	Putative glycerophosphoryl diester phosphodiesterase.	0.588
GDI0283	dnaK	GDI0283	GDI0818	Conserved protein.	Putative chaperone protein dnaK.	0.780
GDI0283	dnaK-2	GDI0283	GDI1262	Conserved protein.	Chaperone protein dnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.780
GDI0950	GDI0147	GDI0950	GDI0147	Putative patatin-like phospholipase.	Putative Acyl-protein thioesterase 1.	0.458
GDI0950	GDI0283	GDI0950	GDI0283	Putative patatin-like phospholipase.	Conserved protein.	0.443
GDI0950	GDI1784	GDI0950	GDI1784	Putative patatin-like phospholipase.	Putative Na+/H+ antiporter.	0.409
GDI0950	GDI3361	GDI0950	GDI3361	Putative patatin-like phospholipase.	Hypothetical protein.	0.429

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.894

expected number of edges:

10

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007062

Sister chromatid cohesion

9 of 40

2.67

9.23

1.94e-19

GO:0007064

Mitotic sister chromatid cohesion

8 of 24

2.84

8.98

3.79e-18

GO:0071168

Protein localization to chromatin

6 of 11

3.05

7.22

3.71e-14

GO:0071921

Cohesin loading

4 of 4

3.32

4.95

1.03e-09

GO:0000278

Mitotic cell cycle

10 of 481

1.64

3.61

2.08e-13

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0061775

Cohesin loading activity

2 of 2

3.32

1.37

0.0034

GO:0003682

Chromatin binding

4 of 420

1.3

0.61

0.0465

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0090694

Scc2-Scc4 cohesin loading complex

4 of 4

3.32

4.73

2.55e-09

GO:0000794

Condensed nuclear chromosome

5 of 49

2.33

3.95

1.16e-08

GO:0000798

Nuclear cohesin complex

3 of 5

3.1

3.26

1.17e-06

GO:0000795

Synaptonemal complex

3 of 22

2.45

2.38e-05

GO:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

2.17

0.00012

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7532

Cohesin Loading onto Chromatin

11 of 20

3.06

14.81

1.89e-29

CL:7535

Cohesin Loading onto Chromatin

8 of 15

3.04

10.11

7.26e-20

CL:7537

Establishment of Sister Chromatid Cohesion

4 of 6

3.14

4.45

7.59e-09

CL:7552

Cohesin complex

2 of 5

2.92

1.3

0.0044

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-2470946

Cohesin Loading onto Chromatin

11 of 20

3.06

15.04

6.30e-30

MAP-68884

Mitotic Telophase/Cytokinesis

11 of 23

3.0

14.76

1.06e-29

MAP-2468052

Establishment of Sister Chromatid Cohesion

7 of 19

2.88

8.23

1.85e-16

MAP-2500257

Resolution of Sister Chromatid Cohesion

7 of 165

1.95

4.08

9.21e-11

MAP-68886

M Phase

11 of 529

1.64

3.95

4.79e-16

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032116

SMC loading complex

4 of 4

3.32

4.69

3.10e-09

GOCC:0090694

Scc2-Scc4 cohesin loading complex

3 of 3

3.32

3.31

1.02e-06

GOCC:0000793

Condensed chromosome

5 of 110

1.98

2.77

1.02e-06

GOCC:0008278

Cohesin complex

3 of 14

2.65

2.57

1.72e-05

GOCC:0034990

Nuclear mitotic cohesin complex

2 of 2

3.32

1.94

0.00032

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0131

Cell cycle

2 of 31

2.13

0.77

0.0368

KW-0539

Nucleus

5 of 1189

0.94

0.52

0.0368

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF12830

Sister chromatid cohesion C-terminus

2 of 2

3.32

1.41

0.0029

PF12765

HEAT repeat associated with sister chromatid cohesion

2 of 4

3.02

1.41

0.0029

PF07814

Wings apart-like protein regulation of heterochromatin

2 of 2

3.32

1.41

0.0029

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR033031

Scc2/Nipped-B family

3 of 3

3.32

2.9

5.87e-06

IPR011989

Armadillo-like helical

6 of 228

1.74

2.3

3.38e-06

IPR039874

Wings apart-like protein

2 of 2

3.32

1.48

0.0022

IPR039776

Sister chromatid cohesion protein Pds5

2 of 2

3.32

1.48

0.0022

IPR024986

Sister chromatid cohesion C-terminal domain

2 of 2

3.32

1.48

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00968

SMC proteins Flexible Hinge Domain

2 of 7

2.77

1.23

0.0059

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