node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GDI0656 | cysG | GDI0656 | GDI0165 | Putative nitroreductase protein. | Putative siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.978 |
GDI0656 | hemE | GDI0656 | GDI1215 | Putative nitroreductase protein. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.463 |
GDI2069 | bedA | GDI2069 | GDI2681 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | 0.633 |
GDI2069 | cysC | GDI2069 | GDI3237 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. | 0.602 |
GDI2069 | cysG | GDI2069 | GDI0165 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Putative siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.952 |
GDI2069 | hemB | GDI2069 | GDI3014 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Putative delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. | 0.956 |
GDI2069 | hemC | GDI2069 | GDI2070 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.998 |
GDI2069 | hemE | GDI2069 | GDI1215 | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.907 |
bedA | GDI2069 | GDI2681 | GDI2069 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.633 |
bedA | cysC | GDI2681 | GDI3237 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. | 0.461 |
bedA | cysD | GDI2681 | GDI3236 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Putative sulfate adenylyltransferase subunit 2. | 0.867 |
bedA | cysG | GDI2681 | GDI0165 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Putative siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.976 |
bedA | cysH | GDI2681 | GDI3235 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Putative phosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. | 0.867 |
bedA | hemC | GDI2681 | GDI2070 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.528 |
bedA | hemE | GDI2681 | GDI1215 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.461 |
bedA | sir2 | GDI2681 | GDI3239 | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | Putative sulfite reductase. | 0.940 |
cysC | GDI2069 | GDI3237 | GDI2069 | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. | Putative uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.602 |
cysC | bedA | GDI3237 | GDI2681 | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. | Putative benzene 1,2-dioxygenase system ferredoxin--NAD(+) reductase subunit. | 0.461 |
cysC | cysD | GDI3237 | GDI3236 | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. | Putative sulfate adenylyltransferase subunit 2. | 0.999 |
cysC | cysG | GDI3237 | GDI0165 | Putative sulfate adenylyltransferase subunit 1; Catalyzes the synthesis of activated sulfate. | Putative siroheme synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.983 |