node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GDI0637 | hisC | GDI0637 | GDI0282 | Putative prephenate dehydrogenase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.945 |
cobQ | hisC | GDI0034 | GDI0282 | Putative cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.916 |
hisA | hisB | GDI0070 | GDI0073 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Putative imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | GDI0070 | GDI0282 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.927 |
hisA | hisD | GDI0070 | GDI1440 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.994 |
hisA | hisF | GDI0070 | GDI0069 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Putative imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisA | hisG | GDI0070 | GDI1441 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.992 |
hisA | hisH | GDI0070 | GDI0071 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Putative imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisA | hisI | GDI0070 | GDI3267 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
hisB | hisA | GDI0073 | GDI0070 | Putative imidazoleglycerol-phosphate dehydratase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | 0.998 |
hisB | hisC | GDI0073 | GDI0282 | Putative imidazoleglycerol-phosphate dehydratase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.999 |
hisB | hisD | GDI0073 | GDI1440 | Putative imidazoleglycerol-phosphate dehydratase. | Putative histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | GDI0073 | GDI0069 | Putative imidazoleglycerol-phosphate dehydratase. | Putative imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | GDI0073 | GDI1441 | Putative imidazoleglycerol-phosphate dehydratase. | Putative ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.988 |
hisB | hisH | GDI0073 | GDI0071 | Putative imidazoleglycerol-phosphate dehydratase. | Putative imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
hisB | hisI | GDI0073 | GDI3267 | Putative imidazoleglycerol-phosphate dehydratase. | Putative phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.998 |
hisC | GDI0637 | GDI0282 | GDI0637 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Putative prephenate dehydrogenase. | 0.945 |
hisC | cobQ | GDI0282 | GDI0034 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Putative cobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. | 0.916 |
hisC | hisA | GDI0282 | GDI0070 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase. | 0.927 |
hisC | hisB | GDI0282 | GDI0073 | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | Putative imidazoleglycerol-phosphate dehydratase. | 0.999 |