| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AraC-2 | GDI1377 | GDI1376 | GDI1377 | Putative AraC-family transcriptional regulator. | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.531 |
| AraC-2 | GDI1380 | GDI1376 | GDI1380 | Putative AraC-family transcriptional regulator. | Aldo/keto reductase family. | 0.440 |
| AraC-2 | hrcA | GDI1376 | GDI1379 | Putative AraC-family transcriptional regulator. | Putative heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.409 |
| AraC-2 | rph | GDI1376 | GDI1378 | Putative AraC-family transcriptional regulator. | Putative Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.531 |
| GDI0740 | GDI1380 | GDI0740 | GDI1380 | Oxidoreductase. | Aldo/keto reductase family. | 0.436 |
| GDI0740 | GDI2662 | GDI0740 | GDI2662 | Oxidoreductase. | Putative amidohydrolases. | 0.429 |
| GDI0740 | glcK | GDI0740 | GDI1864 | Oxidoreductase. | Glucokinase protein. | 0.413 |
| GDI0740 | pdxH | GDI0740 | GDI3232 | Oxidoreductase. | Putative pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). | 0.413 |
| GDI1377 | AraC-2 | GDI1377 | GDI1376 | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative AraC-family transcriptional regulator. | 0.531 |
| GDI1377 | GDI1380 | GDI1377 | GDI1380 | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Aldo/keto reductase family. | 0.511 |
| GDI1377 | hrcA | GDI1377 | GDI1379 | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.636 |
| GDI1377 | mrcA | GDI1377 | GDI1381 | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative penicillin-binding protein 1A. | 0.409 |
| GDI1377 | rph | GDI1377 | GDI1378 | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.993 |
| GDI1380 | AraC-2 | GDI1380 | GDI1376 | Aldo/keto reductase family. | Putative AraC-family transcriptional regulator. | 0.440 |
| GDI1380 | GDI0740 | GDI1380 | GDI0740 | Aldo/keto reductase family. | Oxidoreductase. | 0.436 |
| GDI1380 | GDI1377 | GDI1380 | GDI1377 | Aldo/keto reductase family. | Putative HAM1 protein homolog; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.511 |
| GDI1380 | GDI1640 | GDI1380 | GDI1640 | Aldo/keto reductase family. | Oxidoreductase. | 0.446 |
| GDI1380 | GDI2662 | GDI1380 | GDI2662 | Aldo/keto reductase family. | Putative amidohydrolases. | 0.429 |
| GDI1380 | glcK | GDI1380 | GDI1864 | Aldo/keto reductase family. | Glucokinase protein. | 0.413 |
| GDI1380 | hrcA | GDI1380 | GDI1379 | Aldo/keto reductase family. | Putative heat-inducible transcription repressor hrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.714 |