| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GDI2240 | apt | GDI2240 | GDI1344 | Putative peptidase protein; Belongs to the peptidase M50B family. | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.622 |
| GDI2240 | gltB | GDI2240 | GDI2111 | Putative peptidase protein; Belongs to the peptidase M50B family. | Putative glutamate synthase [NADPH] large chain precursor. | 0.637 |
| GDI2240 | guaB | GDI2240 | GDI1811 | Putative peptidase protein; Belongs to the peptidase M50B family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.560 |
| GDI2240 | murI | GDI2240 | GDI1827 | Putative peptidase protein; Belongs to the peptidase M50B family. | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.548 |
| apt | GDI2240 | GDI1344 | GDI2240 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative peptidase protein; Belongs to the peptidase M50B family. | 0.622 |
| apt | gltB | GDI1344 | GDI2111 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative glutamate synthase [NADPH] large chain precursor. | 0.453 |
| apt | guaB | GDI1344 | GDI1811 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.933 |
| apt | murB | GDI1344 | GDI3193 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.405 |
| apt | murI | GDI1344 | GDI1827 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.540 |
| apt | nadE | GDI1344 | GDI0919 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Putative glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.495 |
| apt | pyrE | GDI1344 | GDI1828 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.611 |
| gltB | GDI2240 | GDI2111 | GDI2240 | Putative glutamate synthase [NADPH] large chain precursor. | Putative peptidase protein; Belongs to the peptidase M50B family. | 0.637 |
| gltB | apt | GDI2111 | GDI1344 | Putative glutamate synthase [NADPH] large chain precursor. | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.453 |
| gltB | guaB | GDI2111 | GDI1811 | Putative glutamate synthase [NADPH] large chain precursor. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.942 |
| gltB | murB | GDI2111 | GDI3193 | Putative glutamate synthase [NADPH] large chain precursor. | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. | 0.939 |
| gltB | murD | GDI2111 | GDI3189 | Putative glutamate synthase [NADPH] large chain precursor. | Putative UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.520 |
| gltB | murI | GDI2111 | GDI1827 | Putative glutamate synthase [NADPH] large chain precursor. | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.599 |
| gltB | nadE | GDI2111 | GDI0919 | Putative glutamate synthase [NADPH] large chain precursor. | Putative glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.917 |
| gltB | nitA | GDI2111 | GDI3743 | Putative glutamate synthase [NADPH] large chain precursor. | Putative nitrilase. | 0.903 |
| gltB | topA | GDI2111 | GDI0045 | Putative glutamate synthase [NADPH] large chain precursor. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.813 |