| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GDI0931 | GDI3830 | GDI0931 | GDI3830 | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Putative aldolase protein. | 0.427 |
| GDI0931 | apt | GDI0931 | GDI1344 | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.759 |
| GDI0931 | deoD | GDI0931 | GDI2055 | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.742 |
| GDI0931 | mtnA | GDI0931 | GDI2233 | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Translation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.736 |
| GDI0931 | mtnB | GDI0931 | GDI0585 | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.478 |
| GDI0931 | mtnK | GDI0931 | GDI3122 | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | Putative kinase; Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate. | 0.736 |
| GDI2382 | GDI3830 | GDI2382 | GDI3830 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Putative aldolase protein. | 0.502 |
| GDI2382 | mtnA | GDI2382 | GDI2233 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Translation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.780 |
| GDI2382 | mtnB | GDI2382 | GDI0585 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.566 |
| GDI3830 | GDI0931 | GDI3830 | GDI0931 | Putative aldolase protein. | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.427 |
| GDI3830 | GDI2382 | GDI3830 | GDI2382 | Putative aldolase protein. | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. | 0.502 |
| GDI3830 | deoD | GDI3830 | GDI2055 | Putative aldolase protein. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.562 |
| GDI3830 | metH | GDI3830 | GDI3502 | Putative aldolase protein. | Putative methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.589 |
| GDI3830 | mtnA | GDI3830 | GDI2233 | Putative aldolase protein. | Translation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.672 |
| GDI3830 | mtnB | GDI3830 | GDI0585 | Putative aldolase protein. | Methylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Belongs to the aldolase class II family. MtnB subfamily. | 0.598 |
| GDI3830 | mtnC | GDI3830 | GDI0587 | Putative aldolase protein. | Enolase-phosphatase; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family. | 0.539 |
| GDI3830 | mtnD | GDI3830 | GDI0586 | Putative aldolase protein. | 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. | 0.680 |
| apt | GDI0931 | GDI1344 | GDI0931 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Conserved hypothetical protein; Belongs to the multicopper oxidase YfiH/RL5 family. | 0.759 |
| apt | deoD | GDI1344 | GDI2055 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 5'-methylthioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.981 |
| apt | mtnA | GDI1344 | GDI2233 | Putative adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Translation initiation factor; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). | 0.766 |