| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GDI1503 | GDI3632 | GDI1503 | GDI3632 | Dihydroorotate dehydrogenase. | Putative amidohydrolase. | 0.878 |
| GDI1503 | glyA | GDI1503 | GDI3012 | Dihydroorotate dehydrogenase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.475 |
| GDI1503 | guaA | GDI1503 | GDI3147 | Dihydroorotate dehydrogenase. | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | 0.926 |
| GDI1503 | pyrF | GDI1503 | GDI1329 | Dihydroorotate dehydrogenase. | Putative Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.938 |
| GDI1503 | udp | GDI1503 | GDI2696 | Dihydroorotate dehydrogenase. | Putative uridine phosphorylase. | 0.947 |
| GDI1503 | upp | GDI1503 | GDI3345 | Dihydroorotate dehydrogenase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.934 |
| GDI3346 | upp | GDI3346 | GDI3345 | Putative peptide methionine sulfoxide reductase; Belongs to the MsrB Met sulfoxide reductase family. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.773 |
| GDI3632 | GDI1503 | GDI3632 | GDI1503 | Putative amidohydrolase. | Dihydroorotate dehydrogenase. | 0.878 |
| GDI3632 | udp | GDI3632 | GDI2696 | Putative amidohydrolase. | Putative uridine phosphorylase. | 0.445 |
| GDI3632 | upp | GDI3632 | GDI3345 | Putative amidohydrolase. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.908 |
| glyA | GDI1503 | GDI3012 | GDI1503 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Dihydroorotate dehydrogenase. | 0.475 |
| glyA | guaA | GDI3012 | GDI3147 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | 0.914 |
| glyA | pyrF | GDI3012 | GDI1329 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.750 |
| glyA | pyrH | GDI3012 | GDI2151 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.421 |
| glyA | upp | GDI3012 | GDI3345 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. | 0.918 |
| guaA | GDI1503 | GDI3147 | GDI1503 | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | Dihydroorotate dehydrogenase. | 0.926 |
| guaA | glyA | GDI3147 | GDI3012 | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.914 |
| guaA | mazG | GDI3147 | GDI2259 | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | Putative protein mazG. | 0.879 |
| guaA | pyrF | GDI3147 | GDI1329 | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | Putative Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.830 |
| guaA | pyrH | GDI3147 | GDI2151 | Gmp synthase [glutamine-hydrolyzing] (glutamin amidotransferase) (gmp synthetase); Catalyzes the synthesis of GMP from XMP. | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. | 0.779 |