node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
GDI0420 | ilvC | GDI0420 | GDI0024 | Putative tartrate dehydrogenase/decarboxylase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.855 |
GDI0420 | ilvD | GDI0420 | GDI3847 | Putative tartrate dehydrogenase/decarboxylase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.784 |
GDI0420 | ilvH | GDI0420 | GDI0023 | Putative tartrate dehydrogenase/decarboxylase. | Putative acetolactate synthase isozyme III small subunit. | 0.937 |
GDI0420 | leuA | GDI0420 | GDI2339 | Putative tartrate dehydrogenase/decarboxylase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.800 |
GDI0420 | leuB | GDI0420 | GDI3085 | Putative tartrate dehydrogenase/decarboxylase. | Putative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.519 |
GDI0420 | leuC | GDI0420 | GDI3087 | Putative tartrate dehydrogenase/decarboxylase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.974 |
GDI0420 | leuD | GDI0420 | GDI3086 | Putative tartrate dehydrogenase/decarboxylase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.945 |
GDI0420 | nifV | GDI0420 | GDI0449 | Putative tartrate dehydrogenase/decarboxylase. | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.818 |
GDI1991 | ilvC | GDI1991 | GDI0024 | Isocitrate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.835 |
GDI1991 | ilvD | GDI1991 | GDI3847 | Isocitrate dehydrogenase. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.784 |
GDI1991 | ilvH | GDI1991 | GDI0023 | Isocitrate dehydrogenase. | Putative acetolactate synthase isozyme III small subunit. | 0.928 |
GDI1991 | leuA | GDI1991 | GDI2339 | Isocitrate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.797 |
GDI1991 | leuB | GDI1991 | GDI3085 | Isocitrate dehydrogenase. | Putative 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.524 |
GDI1991 | leuC | GDI1991 | GDI3087 | Isocitrate dehydrogenase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.948 |
GDI1991 | leuD | GDI1991 | GDI3086 | Isocitrate dehydrogenase. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.937 |
GDI1991 | nifV | GDI1991 | GDI0449 | Isocitrate dehydrogenase. | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.840 |
ilvC | GDI0420 | GDI0024 | GDI0420 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Putative tartrate dehydrogenase/decarboxylase. | 0.855 |
ilvC | GDI1991 | GDI0024 | GDI1991 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Isocitrate dehydrogenase. | 0.835 |
ilvC | ilvD | GDI0024 | GDI3847 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.997 |
ilvC | ilvH | GDI0024 | GDI0023 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Putative acetolactate synthase isozyme III small subunit. | 0.999 |