node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
cctB | dnaJ | rrnAC2939 | rrnAC0839 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Chaperone protein DnaJ. | 0.770 |
cctB | dnaJ2 | rrnAC2939 | rrnAC3334 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.770 |
cctB | dnaK | rrnAC2939 | rrnAC3339 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Chaperone protein DnaK; Acts as a chaperone. | 0.925 |
cctB | eif1A1 | rrnAC2939 | rrnAC2474 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Translation initiation factor 1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. | 0.777 |
cctB | grpE | rrnAC2939 | rrnAC3340 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Heat shock protein GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.902 |
cctB | infB | rrnAC2939 | rrnAC3203 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. | 0.799 |
cctB | lon | rrnAC2939 | rrnAC1914 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | ATP-dependent protease LA; Belongs to the peptidase S16 family. | 0.788 |
cctB | pfdA | rrnAC2939 | rrnAC3116 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Unknown; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.765 |
cctB | psmA4 | rrnAC2939 | rrnAC1174 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.772 |
cctB | tbpE | rrnAC2939 | rrnAC0681 | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | TATA-box binding protein E; General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. | 0.813 |
dnaJ | cctB | rrnAC0839 | rrnAC2939 | Chaperone protein DnaJ. | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | 0.770 |
dnaJ | dnaK | rrnAC0839 | rrnAC3339 | Chaperone protein DnaJ. | Chaperone protein DnaK; Acts as a chaperone. | 0.995 |
dnaJ | grpE | rrnAC0839 | rrnAC3340 | Chaperone protein DnaJ. | Heat shock protein GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.967 |
dnaJ | lon | rrnAC0839 | rrnAC1914 | Chaperone protein DnaJ. | ATP-dependent protease LA; Belongs to the peptidase S16 family. | 0.734 |
dnaJ2 | cctB | rrnAC3334 | rrnAC2939 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | 0.770 |
dnaJ2 | dnaK | rrnAC3334 | rrnAC3339 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Chaperone protein DnaK; Acts as a chaperone. | 0.999 |
dnaJ2 | grpE | rrnAC3334 | rrnAC3340 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Heat shock protein GrpE protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] | 0.975 |
dnaJ2 | infB | rrnAC3334 | rrnAC3203 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | Translation initiation factor IF-2; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. | 0.444 |
dnaJ2 | lon | rrnAC3334 | rrnAC1914 | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | ATP-dependent protease LA; Belongs to the peptidase S16 family. | 0.737 |
dnaK | cctB | rrnAC3339 | rrnAC2939 | Chaperone protein DnaK; Acts as a chaperone. | Thermosome subunit 2; chaperonin beta subunit; Belongs to the TCP-1 chaperonin family. | 0.925 |