STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
fhuAOuter membrane pore protein, receptor for ferrichrome, colicin M, and phages T1, T5 and phi80. (735 aa)    
Predicted Functional Partners:
tonB
Energy transducer; Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins. Belongs to the TonB family.
 
 
 0.926
fhuD
Hydroxamate-dependent iron transport protein (ABC superfamily, peri_bind).
 
  
 0.923
fhuC
ATP-binding component of hydroxymate-dependent iron transport.
 
  
 0.904
fhuB
Hydroxamate-dependent iron transport protein (ABC superfamily, membrane); Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.
 
  
 0.900
exbB
Hypothetical protein; Uptake of enterobactin; tonB-dependent uptake of B colicins.
 
  
 0.837
KPN_02070
TonB protein.
  
 
 0.829
fepA
Outer membrane porin, receptor for ferric enterobactin and colicins B and D.
 
 
 0.816
exbD
Hypothetical protein; Uptake of enterobactin; tonB-dependent uptake of B colicins.
 
  
 0.792
fhuF
Ferric hydroxamate transport protein.
 
  
 0.728
btuB
Outer membrane porin: vitamin B12/cobalamin transport, receptor for E colicins, bacteriophage BF23; Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans- periplasmic membrane protein TonB; Belongs to the TonB-dependent receptor family. BtuB (TC 1.B.14.3.1) subfamily.
 
  
 0.658
Your Current Organism:
Klebsiella pneumoniae MGH78578
NCBI taxonomy Id: 272620
Other names: K. pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae MCG 78578, Klebsiella pneumoniae str. MCG 78578, Klebsiella pneumoniae subsp. pneumoniae ATCC 700721, Klebsiella pneumoniae subsp. pneumoniae MGH 78578, Klebsiella pneumoniae subsp. pneumoniae str. MGH 78578, Klebsiella pneumoniae subsp. pneumoniae strain MGH 78578
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.