STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
manMMannose-specific PTS system component IIC; COG3715 Phosphotransferase system, mannose-fructose -N-acetylgalactosamine-specific. (269 aa)    
Predicted Functional Partners:
manL
Mannose-specific PTS system component IIAB.
 
 0.999
manN
Mannose-specific PTS system component IID; COG3716 Phosphotransferase system, mannose-fructose -N-acetylgalactosamine-specific.
 0.999
LBA1684
Putative PTS system, IIA component; COG2893 Phosphotransferase system, mannose-fructose-specific component IIA.
 
 0.992
LBA0457
Hypothetical protein.
 
  
 0.989
ptsH
Phosphocarrier protein HPr; PthP; COG1925 Phosphotransferase system, HPr-related protein.
  
 
 0.929
LBA0745
COG1482 Phosphomannose isomerase; Belongs to the mannose-6-phosphate isomerase type 1 family.
 
  
 0.922
fruA
PTS system, fructose-specific enzyme II.
  
  
 0.851
LBA0016
Fructokinase; COG1940 transcriptional regulator-sugar kinase.
    
 0.810
smpB
ssrA-binding protein; Required for rescue of stalled ribosomes mediated by trans- translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to [...]
      
 0.639
mecA
Negative regulator genetic competence; Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis; Belongs to the MecA family.
      
 0.639
Your Current Organism:
Lactobacillus acidophilus
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.