STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hmdHHmdH; COG1257 Hydroxymethylglutaryl-CoA reductase. (403 aa)    
Predicted Functional Partners:
hmcS
HmcS; COG3425 3-hydroxy-3-methylglutaryl CoA synthase.
 
 0.999
mvaK
Mevalonate kinase.
 0.999
thil
acetyl-CoA C-acetyltransferase thil; COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family.
 
  
 0.990
mvaD
Mevalonate diphosphate decarboxylase.
 
  
 0.978
fni
Isopentenyl diphosphate isomerase; Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).
   
 0.846
LBA1169
Phosphomevalonate kinase.
 
 
 0.751
ampM
Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
     
 0.547
LBA1329
COG0142 Geranylgeranyl pyrophosphate synthase; Belongs to the FPP/GGPP synthase family.
  
 
 0.544
LBA0117
Putative transcriptional regulator; Family; Sir2.
  
  
 0.538
LBA0625
UTP-glucose-1-phosphate uridylyltransferase; COG1210 UDP-glucose pyrophosphorylase.
       0.530
Your Current Organism:
Lactobacillus acidophilus
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.