Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
Experiments
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[Homology]
Score
pgsACDP-diacylglycerol- phosphatephosphatidyltransferase; PgsA; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (186 aa)    
Predicted Functional Partners:
LBA0663
Putative transcriptional regulator.
  
    0.980
cdsA
Phosphatidate cytidylyltransferase; CdsA; COG0575 CDP-diglyceride synthetase.
 
 
 0.966
acmA
N-acetylmuramidase; COG1705 Muramidase (flagellum-specific).
     
 0.855
fabG
3-oxoacyl-(acyl-carrier protein) reductase; FabG.
  
 
 0.816
LBA0660
Putative protease; COG0612 Predicted Zn-dependent peptidases.
  
  
 0.777
LBA0661
Protease; COG0612 Predicted Zn-dependent peptidases.
  
  
 0.777
mprF
Hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms.
  
  
 0.740
LBA0657
rRNA methylase; Could methylate the ribose at the nucleotide 34 wobble position in tRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.
 
     0.697
LBA0659
Sporulation protein -putative cell division protein FtsK; SpoIIIe; Belongs to the FtsK/SpoIIIE/SftA family.
  
  
 0.695
gidB
Glucose inhibited division protein B; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.
  
  
 0.690
Your Current Organism:
Lactobacillus acidophilus
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
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