Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
metAHomoserine O-succinyltransferase; Transfers an acetyl group from acetyl-CoA to L-serine, forming acetyl-L-serine; Belongs to the MetA family. (262 aa)    
Predicted Functional Partners:
LBA1238
Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family.
 
  
 0.985
LBA1212
Homoserine dehydrogenase Hdh.
  
 
 0.929
LBA0850
COG0527 Aspartokinases; Belongs to the aspartokinase family.
 
  
 0.919
LBA1087
Cysteine synthase; Potential frameshift to 1088.
    
 0.919
LBA1215
Aspartokinase; ThrA2; COG0527 Aspartokinases; Belongs to the aspartokinase family.
 
  
 0.907
sdhB
L-serine dehydratase, beta subunit.
    
 0.904
sdhA
L-serine dehydratase, alpha subunit; Belongs to the iron-sulfur dependent L-serine dehydratase family.
    
 0.904
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
  
 0.880
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
  0.800
alr
Ala racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family.
     
 0.792
Your Current Organism:
Lactobacillus acidophilus
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
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