node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
clpC | clpP | LBA0283 | LBA0694 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease P; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.924 |
clpC | dnaJ | LBA0283 | LBA1246 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | 0.810 |
clpC | dnaK | LBA0283 | LBA1247 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | Heat shock protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
clpC | groL | LBA0283 | LBA0406 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.853 |
clpC | groS | LBA0283 | LBA0405 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | Cochaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.789 |
clpC | grpE | LBA0283 | LBA1248 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | Cochaperonin, Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] | 0.753 |
clpC | hrcA | LBA0283 | LBA1249 | ATPase; ClpC; Belongs to the ClpA/ClpB family. | Inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.706 |
clpE | clpP | LBA0638 | LBA0694 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease P; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.945 |
clpE | dnaJ | LBA0638 | LBA1246 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | 0.809 |
clpE | dnaK | LBA0638 | LBA1247 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
clpE | groL | LBA0638 | LBA0406 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.863 |
clpE | groS | LBA0638 | LBA0405 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.852 |
clpE | grpE | LBA0638 | LBA1248 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin, Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] | 0.853 |
clpE | hrcA | LBA0638 | LBA1249 | ATP-dependent Clp protease, ATP-binding subunit; ClpE; Belongs to the ClpA/ClpB family. | Inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.700 |
clpE-2 | clpP | LBA1910 | LBA0694 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease P; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.946 |
clpE-2 | dnaJ | LBA1910 | LBA1246 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...] | 0.810 |
clpE-2 | dnaK | LBA1910 | LBA1247 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Heat shock protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.955 |
clpE-2 | groL | LBA1910 | LBA0406 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Chaperonin; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.853 |
clpE-2 | groS | LBA1910 | LBA0405 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.852 |
clpE-2 | grpE | LBA1910 | LBA1248 | ATP-dependent protease; ClpE; Belongs to the ClpA/ClpB family. | Cochaperonin, Hsp70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of [...] | 0.824 |