STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lacLBeta-galactosidase large subunit (lactase); Belongs to the glycosyl hydrolase 2 family. (628 aa)    
Predicted Functional Partners:
lacM
Beta-galactosidase small subunit.
 
 0.999
lacZ
Beta-galactosidase; Catalyzes the hydrolysis of lactose to its constituent monosaccharides glucose and galactose; Belongs to the glycosyl hydrolase 42 family.
  
 0.984
lacA
Beta-galactosidase.
  
 0.969
melA
Alpha-galactosidase; Hydrolyzes the short-chain alpha-galactosaccharide raffinose. Belongs to the glycosyl hydrolase 36 family.
 
 
 0.968
lacS
Lactose permease.
 
  
 0.963
fruK
Fructose-1-phosphate kinase; FruK; Belongs to the carbohydrate kinase PfkB family. LacC subfamily.
  
  
 0.952
galM
Galactose-1-epimerase; Mutarotase.
  
 
 0.948
lacR
Transcription repressor of beta-galactosidasegene; Lactose transcriptional regulator.
 
   
 0.881
galK
Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily.
 
  
 0.811
galE
UDP-galactose 4-epimerase; Belongs to the NAD(P)-dependent epimerase/dehydratase family.
  
  
 0.740
Your Current Organism:
Lactobacillus acidophilus
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.