Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LBA1901Thioredoxin 2. (103 aa)    
Predicted Functional Partners:
trxR
Thioredoxin reductase.
  
 
 0.733
msrA
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 0.720
dnaK
Heat shock protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 0.676
dnaJ
Heat shock protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]
   
 0.638
LBA1107
Glutathione reductase; COG1249 Pyruvate-2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component.
  
 0.624
LBA1220
Pyridine mercuric reductase; COG1249 Pyruvate-2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component.
  
 0.624
LBA1899
Putative transcriptional regulator; Family; ArsR; COG0607 Rhodanese-related sulfurtransferase.
     
 0.624
LBA1126
Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.
   
 0.580
LBA0515
Hypothetical protein.
  
 0.554
frnE
Protein-disulfide isomerase; FrnE.
  
  
 0.554
Your Current Organism:
Lactobacillus acidophilus
NCBI taxonomy Id: 272621
Other names: L. acidophilus NCFM, Lactobacillus acidophilus NCFM, Lactobacillus acidophilus str. NCFM, Lactobacillus acidophilus strain NCFM
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