node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
asnS | legS1 | lpg2282 | lpg2588 | Asparaginyl tRNA synthetase. | Acid sphingomyelinase-like phosphodiesterase. | 0.827 |
asnS | lpg1922 | lpg2282 | lpg1922 | Asparaginyl tRNA synthetase. | ATP dependent DNA helicase (DEAD box family) Rad3. | 0.803 |
asnS | lpg2256 | lpg2282 | lpg2256 | Asparaginyl tRNA synthetase. | Metallo-beta-lactamase superfamily protein. | 0.576 |
asnS | lpg2403 | lpg2282 | lpg2403 | Asparaginyl tRNA synthetase. | Hypothetical protein. | 0.579 |
asnS | polI | lpg2282 | lpg0099 | Asparaginyl tRNA synthetase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.945 |
asnS | recA | lpg2282 | lpg1801 | Asparaginyl tRNA synthetase. | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.751 |
asnS | recQ | lpg2282 | lpg0867 | Asparaginyl tRNA synthetase. | ATP-dependent DNA helicase RecQ. | 0.836 |
asnS | sidE | lpg2282 | lpg0234 | Asparaginyl tRNA synthetase. | SidE; Effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several host Rab small GTPases associated with the endoplasmic reticulum during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide. The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker that results in the re [...] | 0.812 |
asnS | topA | lpg2282 | lpg2599 | Asparaginyl tRNA synthetase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.861 |
legS1 | asnS | lpg2588 | lpg2282 | Acid sphingomyelinase-like phosphodiesterase. | Asparaginyl tRNA synthetase. | 0.827 |
legS1 | lpg0002 | lpg2588 | lpg0002 | Acid sphingomyelinase-like phosphodiesterase. | DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | 0.781 |
legS1 | lpg1922 | lpg2588 | lpg1922 | Acid sphingomyelinase-like phosphodiesterase. | ATP dependent DNA helicase (DEAD box family) Rad3. | 0.982 |
legS1 | lpg2256 | lpg2588 | lpg2256 | Acid sphingomyelinase-like phosphodiesterase. | Metallo-beta-lactamase superfamily protein. | 0.869 |
legS1 | lpg2403 | lpg2588 | lpg2403 | Acid sphingomyelinase-like phosphodiesterase. | Hypothetical protein. | 0.893 |
legS1 | polI | lpg2588 | lpg0099 | Acid sphingomyelinase-like phosphodiesterase. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.997 |
legS1 | recA | lpg2588 | lpg1801 | Acid sphingomyelinase-like phosphodiesterase. | RecA bacterial DNA recombination protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.925 |
legS1 | recQ | lpg2588 | lpg0867 | Acid sphingomyelinase-like phosphodiesterase. | ATP-dependent DNA helicase RecQ. | 0.993 |
legS1 | sidE | lpg2588 | lpg0234 | Acid sphingomyelinase-like phosphodiesterase. | SidE; Effector that interferes with the host cell ubiquitin pathway and is required for intracellular bacterial replication. Catalyzes the ubiquitination of several host Rab small GTPases associated with the endoplasmic reticulum during L.pneumophila infection, without engaging the standard cellular enzyme cascade (E1 and E2). Transfers an ADP-ribose moiety from NAD to the 'Arg-42' residue of ubiquitin in a reaction that releases nicotinamide. The modified ubiquitin is subsequently transferred to serine residues of the substrate protein via a phosphoribose linker that results in the re [...] | 0.999 |
legS1 | topA | lpg2588 | lpg2599 | Acid sphingomyelinase-like phosphodiesterase. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.898 |
lpg0002 | legS1 | lpg0002 | lpg2588 | DNA polymerase III beta chain; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of re [...] | Acid sphingomyelinase-like phosphodiesterase. | 0.781 |