Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lpg1620Hypothetical protein; Transcription factors / DNA binding proteins. (146 aa)    
Predicted Functional Partners:
lpg1618
Beta-lactamase AmpS.
    
 0.894
ftsI4
Cell division protein FtsI/penicillin binding protein 2.
 
     0.859
legLC8
Leucine-rich repeat- and coiled coil-containing protein; Conserved gene, like GALA proteins.
 
  
  0.526
tolC
Agglutination protein.
    
  0.521
lpg2927
Hypothetical protein.
    
  0.489
lpg2401
Putative secreted esterase.
  
     0.464
lpg1621
Hypothetical protein.
       0.463
amiB
N-acetylmuramoyl-L-alanine amidase.
    
  0.443
birA
Biotin operon repressor and biotin [acetyl CoA carboxylase] synthetase BirA bifunctional protein; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
      
 0.426
lpg1509
D-alanyl-D-alanine carboxypeptidase; Belongs to the peptidase S11 family.
     
  0.421
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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