Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
legL3Leucine-rich repeat-containing protein. (493 aa)    
Predicted Functional Partners:
legL5
Leucine-rich repeat-containing protein; FLJ00180 protein; conserved gene.
  
   
 0.891
legL7
Leucine-rich repeat-containing protein.
  
   
 0.888
legLC4
Leucine-rich repeat- and coiled coil-containing protein; FLJ00180 protein; conserved gene.
  
   
 0.839
legL1
Gala protein type 1, 3 or 4; Leucine-rich repeat-containing protein; conserved gene.
  
   
 0.838
legG1
UVB-resistance protein UVR8; Conserved gene; RCC-1.
  
   
 0.833
legLC8
Leucine-rich repeat- and coiled coil-containing protein; Conserved gene, like GALA proteins.
  
   
 0.825
legA14
Ankyrin repeat-containing protein.
  
   
 0.760
legL6
Leucine-rich repeat-containing protein.
  
     0.747
legC5
Coiled-coil-containing protein; Conserved gene; similar to surface antigen of Plasmodium and Entamoeba.
  
   
 0.731
legU2
UBOX-containing protein; Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway. Acts in conjunction with host E2 ubiquitin-conjugating enzymes UBE2D1 (UBCH5A) or UBE2D3 (UBCH5C), and mediates polyubiquitination of host kinase CLK1.
  
   
 0.688
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.