Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
dsbD-2Thiol:disulfide interchange protein DsbD. (459 aa)    
Predicted Functional Partners:
com1
27 kDa outer membrane protein.
  
 
 0.905
msrA
Peptide methionine sulfoxide reductase; Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.
   
 
 0.891
dsbA
Thiol:disulfide interchange protein DsbA.
 
 
 0.802
lpg2423
Hypothetical protein-transmembrane region and signal peptide prediction.
  
 
 0.740
traF
Sex pilus assembly TraF, thiol-disulfide isomerase and thioredoxins.
  
 
 0.700
traF-2
Pilus assembly protein TraF.
  
 
 0.700
htpA
Hsp10, 10 kDa chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.
     
 0.676
dsbE
Thiol:disulfide interchange protein DsbE; Conserved gene, previously annotated as cytochrome c biogenesis protein CcmG in Legionella pneumophila.
     
 0.632
glyS
Glycyl tRNA synthetase, beta subunit.
      
 0.626
uvrD
DNA dependent ATPase I and helicase II.
      
 0.618
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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