setA protein (Legionella pneumophila Philadelphia)

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setA

Hypothetical teichoic acid biosynthesis protein); Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 [...] (644 aa)

Predicted Functional Partners:

lpg2954

0.637

lvrA-2

0.612

lpg2586

0.599

lepB

0.595

legN

0.548

lpg1496

0.541

legS1

0.541

legC8

0.540

lpg0965

0.528

vipA

0.513

Your Current Organism:

Legionella pneumophila Philadelphia

NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
legC8	lpg1496	lpg2862	lpg1496	Coiled-coil containing protein.	Hypothetical protein.	0.451
legC8	setA	lpg2862	lpg1978	Coiled-coil containing protein.	Hypothetical teichoic acid biosynthesis protein); Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 [...]	0.540
legN	legS1	lpg2720	lpg2588	cNMP binding domain-containing protein.	Acid sphingomyelinase-like phosphodiesterase.	0.705
legN	lepB	lpg2720	lpg2490	cNMP binding domain-containing protein.	LepB.	0.766
legN	lpg0965	lpg2720	lpg0965	cNMP binding domain-containing protein.	LphB.	0.697
legN	lpg2954	lpg2720	lpg2954	cNMP binding domain-containing protein.	Hypothetical protein.	0.424
legN	lvrA-2	lpg2720	lpg1259	cNMP binding domain-containing protein.	LvrA.	0.608
legN	setA	lpg2720	lpg1978	cNMP binding domain-containing protein.	Hypothetical teichoic acid biosynthesis protein); Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 [...]	0.548
legS1	legN	lpg2588	lpg2720	Acid sphingomyelinase-like phosphodiesterase.	cNMP binding domain-containing protein.	0.705
legS1	lepB	lpg2588	lpg2490	Acid sphingomyelinase-like phosphodiesterase.	LepB.	0.816
legS1	lpg0965	lpg2588	lpg0965	Acid sphingomyelinase-like phosphodiesterase.	LphB.	0.615
legS1	lpg2586	lpg2588	lpg2586	Acid sphingomyelinase-like phosphodiesterase.	Cysteine protease, papain C1 family.	0.720
legS1	lpg2954	lpg2588	lpg2954	Acid sphingomyelinase-like phosphodiesterase.	Hypothetical protein.	0.657
legS1	lvrA-2	lpg2588	lpg1259	Acid sphingomyelinase-like phosphodiesterase.	LvrA.	0.751
legS1	setA	lpg2588	lpg1978	Acid sphingomyelinase-like phosphodiesterase.	Hypothetical teichoic acid biosynthesis protein); Secreted effector that interferes with vesicular trafficking of host cells. Possesses glucohydrolase and mono-O-glucosyltransferase activity by using UDP-glucose as a sugar donor substrate. Is able to glucosylate histones H4 and H3.1 in vitro, but it is unlikely that histones are the natural substrates for SetA. May glycosylate a component of the host cell vesicle trafficking machinery during L.pneumophila infection. Binds with high specificity to phosphatidylinositol 3-phosphate (PtdIns(3)P), (with a dissociation constant value of 809 [...]	0.541
lepB	legN	lpg2490	lpg2720	LepB.	cNMP binding domain-containing protein.	0.766
lepB	legS1	lpg2490	lpg2588	LepB.	Acid sphingomyelinase-like phosphodiesterase.	0.816
lepB	lpg0965	lpg2490	lpg0965	LepB.	LphB.	0.656
lepB	lpg2954	lpg2490	lpg2954	LepB.	Hypothetical protein.	0.515
lepB	lvrA-2	lpg2490	lpg1259	LepB.	LvrA.	0.661

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