node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisB | lpg1195 | lpg1197 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.999 |
hisA | hisC2 | lpg1195 | lpg1998 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.900 |
hisA | hisD | lpg1195 | lpg1199 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisA | hisF | lpg1195 | lpg0749 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase, cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.985 |
hisA | hisG | lpg1195 | lpg1200 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
hisA | hisH | lpg1195 | lpg0750 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR. | 0.992 |
hisA | hisH_2 | lpg1195 | lpg1196 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR. | 0.998 |
hisA | hisI | lpg1195 | lpg1193 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidine biosynthesis bifunctional protein HisIE; phosphoribosyl-ATP pyrophosphatase/phosphoribosyl AMP cyclohydrolase = histidine biosynthesis bifunctional protein; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | lpg1194 | lpg1195 | lpg1194 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazoleglycerol-phosphate synthase, cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | lysC | lpg1195 | lpg1811 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Aspartokinase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.541 |
hisB | hisA | lpg1197 | lpg1195 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.999 |
hisB | hisC2 | lpg1197 | lpg1998 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.998 |
hisB | hisD | lpg1197 | lpg1199 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |
hisB | hisF | lpg1197 | lpg0749 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase, cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | hisG | lpg1197 | lpg1200 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | ATP phosphoribosyltransferase HisG; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.999 |
hisB | hisH | lpg1197 | lpg0750 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR. | 0.999 |
hisB | hisH_2 | lpg1197 | lpg1196 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Amidotransferase HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR. | 0.999 |
hisB | hisI | lpg1197 | lpg1193 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Histidine biosynthesis bifunctional protein HisIE; phosphoribosyl-ATP pyrophosphatase/phosphoribosyl AMP cyclohydrolase = histidine biosynthesis bifunctional protein; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisB | lpg1194 | lpg1197 | lpg1194 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Imidazoleglycerol-phosphate synthase, cyclase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
hisB | lysC | lpg1197 | lpg1811 | Histidinol phosphatase and imidazoleglycerol-phosphate dehydratase = bifunctional protein HisB; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Aspartokinase; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.526 |