Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hydACytochrome c3 hydrogenase alpha chain. (430 aa)    
Predicted Functional Partners:
lpg2468
Sulfhydrogenase delta subunit.
 
 0.997
vhtD
Hydrogenase expression/formation protein.
 
  
 0.973
lpg2470
Cytochrome c3 hydrogenase alpha (or beta) chain.
 
   
 0.968
hydG-2
Hydrogenase/sulfur reductase gamma subunit.
 
   
 0.965
hypF
Hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
   
 0.910
hypE
Hydrogenase expression/formation protein HypE.
 
   
 0.899
hypD
Hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
   
 0.899
hypC
Hydrogenase expression/formation protein HypC.
 
   
 0.871
hypB
Hydrogenase expression/formation protein HypB.
     
 0.845
hypA
Hydrogenase nickel incorporation protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
     
 0.839
Your Current Organism:
Legionella pneumophila Philadelphia
NCBI taxonomy Id: 272624
Other names: L. pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia 1, Legionella pneumophila subsp. pneumophila str. Philadelphia-1, Legionella pneumophila subsp. pneumophila strain Philadelphia 1
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