node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
dltA | gsaB | gene:17565303 | gene:17566148 | D-alanine-activating enzyme (dae), D-alanine-D-alanyl carrier protein ligase (dcl); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net ch [...] | Glutamate-1-semialdehyde aminotransferase. | 0.899 |
dltA | hemL | gene:17565303 | gene:17565919 | D-alanine-activating enzyme (dae), D-alanine-D-alanyl carrier protein ligase (dcl); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net ch [...] | Highly similar to glutamate-1-semialdehyde 2,1-aminotransferases. | 0.879 |
gsaB | dltA | gene:17566148 | gene:17565303 | Glutamate-1-semialdehyde aminotransferase. | D-alanine-activating enzyme (dae), D-alanine-D-alanyl carrier protein ligase (dcl); Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D- alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net ch [...] | 0.899 |
gsaB | hemA | gene:17566148 | gene:17565923 | Glutamate-1-semialdehyde aminotransferase. | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.990 |
gsaB | hemB | gene:17566148 | gene:17565920 | Glutamate-1-semialdehyde aminotransferase. | Highly similar to delta-aminolevulinic acid dehydratases (porphobilinogen synthase); Belongs to the ALAD family. | 0.992 |
gsaB | hemC | gene:17566148 | gene:17565922 | Glutamate-1-semialdehyde aminotransferase. | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.954 |
gsaB | hemE | gene:17566148 | gene:17566677 | Glutamate-1-semialdehyde aminotransferase. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.664 |
gsaB | hemL | gene:17566148 | gene:17565919 | Glutamate-1-semialdehyde aminotransferase. | Highly similar to glutamate-1-semialdehyde 2,1-aminotransferases. | 0.909 |
gsaB | lin1105 | gene:17566148 | gene:17565435 | Glutamate-1-semialdehyde aminotransferase. | Lin1105 protein; Similar to uroporphyrin-III C-methyltransferase. | 0.497 |
gsaB | lin1164 | gene:17566148 | gene:17565494 | Glutamate-1-semialdehyde aminotransferase. | Lin1164 protein; Similar uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase. | 0.808 |
gsaB | lin1590 | gene:17566148 | gene:17565921 | Glutamate-1-semialdehyde aminotransferase. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.839 |
hemA | gsaB | gene:17565923 | gene:17566148 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate-1-semialdehyde aminotransferase. | 0.990 |
hemA | hemB | gene:17565923 | gene:17565920 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Highly similar to delta-aminolevulinic acid dehydratases (porphobilinogen synthase); Belongs to the ALAD family. | 0.976 |
hemA | hemC | gene:17565923 | gene:17565922 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.997 |
hemA | hemE | gene:17565923 | gene:17566677 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.737 |
hemA | hemL | gene:17565923 | gene:17565919 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Highly similar to glutamate-1-semialdehyde 2,1-aminotransferases. | 0.997 |
hemA | lin1105 | gene:17565923 | gene:17565435 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Lin1105 protein; Similar to uroporphyrin-III C-methyltransferase. | 0.667 |
hemA | lin1164 | gene:17565923 | gene:17565494 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Lin1164 protein; Similar uroporphyrinogen-III methyltransferase/uroporphyrinogen-III synthase. | 0.909 |
hemA | lin1590 | gene:17565923 | gene:17565921 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.976 |
hemB | gsaB | gene:17565920 | gene:17566148 | Highly similar to delta-aminolevulinic acid dehydratases (porphobilinogen synthase); Belongs to the ALAD family. | Glutamate-1-semialdehyde aminotransferase. | 0.992 |