node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
apt | guaA | gene:17565890 | gene:17565411 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.982 |
apt | guaB | gene:17565890 | gene:17567287 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.573 |
apt | lin1998 | gene:17565890 | gene:17566356 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.933 |
apt | pyrG | gene:17565890 | gene:17567084 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.475 |
argS | guaA | gene:17567086 | gene:17565411 | Arginyl tRNA synthetase. | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | 0.978 |
argS | guaB | gene:17567086 | gene:17567287 | Arginyl tRNA synthetase. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.475 |
argS | lin0179 | gene:17567086 | gene:17564491 | Arginyl tRNA synthetase. | Lin0179 protein; Similar to inosine monophosphate dehydrogenase. | 0.562 |
argS | lysS | gene:17567086 | gene:17564572 | Arginyl tRNA synthetase. | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.870 |
argS | pyrG | gene:17567086 | gene:17567084 | Arginyl tRNA synthetase. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.873 |
argS | rplA | gene:17567086 | gene:17564608 | Arginyl tRNA synthetase. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.599 |
argS | tufA | gene:17567086 | gene:17567189 | Arginyl tRNA synthetase. | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. | 0.463 |
guaA | apt | gene:17565411 | gene:17565890 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. | 0.982 |
guaA | argS | gene:17565411 | gene:17567086 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Arginyl tRNA synthetase. | 0.978 |
guaA | guaB | gene:17565411 | gene:17567287 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.999 |
guaA | lin0179 | gene:17565411 | gene:17564491 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Lin0179 protein; Similar to inosine monophosphate dehydrogenase. | 0.998 |
guaA | lin1606 | gene:17565411 | gene:17565937 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.977 |
guaA | lin1998 | gene:17565411 | gene:17566356 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Xanthine phosphoribosyltransferase; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis. | 0.982 |
guaA | lysS | gene:17565411 | gene:17564572 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | lysyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. | 0.982 |
guaA | pyrG | gene:17565411 | gene:17567084 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. | 0.986 |
guaA | rplA | gene:17565411 | gene:17564608 | GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.977 |