| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCC_00469 | CCC_02216 | CCC_00469 | CCC_02216 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | 0.793 |
| CCC_00469 | CCC_03389 | CCC_00469 | CCC_03389 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Aminomethyltransferase (glycine cleavage system T protein). | 0.962 |
| CCC_00469 | CCC_03392 | CCC_00469 | CCC_03392 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase decarboxylating (glycine cleavage system P2 protein). | 0.916 |
| CCC_00469 | CCC_03903 | CCC_00469 | CCC_03903 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. | 0.793 |
| CCC_00469 | dadA | CCC_00469 | CCC_03672 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. | 0.868 |
| CCC_00469 | folD | CCC_00469 | CCC_00697 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.928 |
| CCC_00469 | gcvH | CCC_00469 | CCC_03390 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.915 |
| CCC_00469 | gcvPA | CCC_00469 | CCC_03391 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase decarboxylating (glycine cleavage system P1 protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.890 |
| CCC_00469 | glyA | CCC_00469 | CCC_02233 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.933 |
| CCC_00469 | purH | CCC_00469 | CCC_00871 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Phosphoribosylaminoimidazolecarboxamide formyltransferase. | 0.905 |
| CCC_02216 | CCC_00469 | CCC_02216 | CCC_00469 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.793 |
| CCC_02216 | CCC_03389 | CCC_02216 | CCC_03389 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Aminomethyltransferase (glycine cleavage system T protein). | 0.961 |
| CCC_02216 | CCC_03392 | CCC_02216 | CCC_03392 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Glycine dehydrogenase decarboxylating (glycine cleavage system P2 protein). | 0.958 |
| CCC_02216 | CCC_03903 | CCC_02216 | CCC_03903 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. | 0.892 |
| CCC_02216 | dadA | CCC_02216 | CCC_03672 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | D-amino acid dehydrogenase small subunit; Oxidative deamination of D-amino acids. | 0.645 |
| CCC_02216 | folD | CCC_02216 | CCC_00697 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.907 |
| CCC_02216 | gcvH | CCC_02216 | CCC_03390 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.966 |
| CCC_02216 | gcvPA | CCC_02216 | CCC_03391 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Glycine dehydrogenase decarboxylating (glycine cleavage system P1 protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.925 |
| CCC_02216 | glyA | CCC_02216 | CCC_02233 | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.909 |
| CCC_03389 | CCC_00469 | CCC_03389 | CCC_00469 | Aminomethyltransferase (glycine cleavage system T protein). | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.962 |