| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCC_00445 | CCC_00470 | CCC_00445 | CCC_00470 | Glutamate synthase NADPH large chain. | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.633 |
| CCC_00445 | CCC_02216 | CCC_00445 | CCC_02216 | Glutamate synthase NADPH large chain. | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | 0.893 |
| CCC_00445 | CCC_02225 | CCC_00445 | CCC_02225 | Glutamate synthase NADPH large chain. | Glutamate synthase NADPH large chain. | 0.999 |
| CCC_00445 | CCC_03389 | CCC_00445 | CCC_03389 | Glutamate synthase NADPH large chain. | Aminomethyltransferase (glycine cleavage system T protein). | 0.935 |
| CCC_00445 | CCC_03392 | CCC_00445 | CCC_03392 | Glutamate synthase NADPH large chain. | Glycine dehydrogenase decarboxylating (glycine cleavage system P2 protein). | 0.930 |
| CCC_00445 | CCC_03903 | CCC_00445 | CCC_03903 | Glutamate synthase NADPH large chain. | Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. | 0.893 |
| CCC_00445 | folD | CCC_00445 | CCC_00697 | Glutamate synthase NADPH large chain. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.473 |
| CCC_00445 | gcvH | CCC_00445 | CCC_03390 | Glutamate synthase NADPH large chain. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.938 |
| CCC_00445 | gcvPA | CCC_00445 | CCC_03391 | Glutamate synthase NADPH large chain. | Glycine dehydrogenase decarboxylating (glycine cleavage system P1 protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.939 |
| CCC_00445 | glyA | CCC_00445 | CCC_02233 | Glutamate synthase NADPH large chain. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.940 |
| CCC_00470 | CCC_00445 | CCC_00470 | CCC_00445 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase NADPH large chain. | 0.633 |
| CCC_00470 | CCC_02216 | CCC_00470 | CCC_02216 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Dihydrolipoamide dehydrogenase of pyruvate dehydrogenase complex. | 0.905 |
| CCC_00470 | CCC_02225 | CCC_00470 | CCC_02225 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase NADPH large chain. | 0.633 |
| CCC_00470 | CCC_03389 | CCC_00470 | CCC_03389 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Aminomethyltransferase (glycine cleavage system T protein). | 0.933 |
| CCC_00470 | CCC_03392 | CCC_00470 | CCC_03392 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase decarboxylating (glycine cleavage system P2 protein). | 0.922 |
| CCC_00470 | CCC_03903 | CCC_00470 | CCC_03903 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Dihydrolipoamide dehydrogenase of 2-oxoglutarate dehydrogenase. | 0.905 |
| CCC_00470 | folD | CCC_00470 | CCC_00697 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.942 |
| CCC_00470 | gcvH | CCC_00470 | CCC_03390 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.932 |
| CCC_00470 | gcvPA | CCC_00470 | CCC_03391 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase decarboxylating (glycine cleavage system P1 protein); The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. | 0.922 |
| CCC_00470 | glyA | CCC_00470 | CCC_02233 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |