| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCC_00445 | CCC_00469 | CCC_00445 | CCC_00469 | Glutamate synthase NADPH large chain. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.425 |
| CCC_00445 | CCC_00470 | CCC_00445 | CCC_00470 | Glutamate synthase NADPH large chain. | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.633 |
| CCC_00445 | CCC_02225 | CCC_00445 | CCC_02225 | Glutamate synthase NADPH large chain. | Glutamate synthase NADPH large chain. | 0.999 |
| CCC_00445 | CCC_03496 | CCC_00445 | CCC_03496 | Glutamate synthase NADPH large chain. | Sensory transduction histidine kinase. | 0.402 |
| CCC_00445 | CCC_03497 | CCC_00445 | CCC_03497 | Glutamate synthase NADPH large chain. | Hypothetical protein. | 0.673 |
| CCC_00445 | hemE | CCC_00445 | CCC_00939 | Glutamate synthase NADPH large chain. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.762 |
| CCC_00469 | CCC_00445 | CCC_00469 | CCC_00445 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase NADPH large chain. | 0.425 |
| CCC_00469 | CCC_00470 | CCC_00469 | CCC_00470 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.998 |
| CCC_00469 | CCC_02225 | CCC_00469 | CCC_02225 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glutamate synthase NADPH large chain. | 0.425 |
| CCC_00469 | CCC_02451 | CCC_00469 | CCC_02451 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | 0.952 |
| CCC_00469 | CCC_03497 | CCC_00469 | CCC_03497 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Hypothetical protein. | 0.844 |
| CCC_00469 | CCC_04199 | CCC_00469 | CCC_04199 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | 0.962 |
| CCC_00469 | ahcY | CCC_00469 | CCC_00680 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.959 |
| CCC_00469 | hemE | CCC_00469 | CCC_00939 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Uroporphyrinogen III decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.743 |
| CCC_00469 | metK | CCC_00469 | CCC_01005 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.957 |
| CCC_00470 | CCC_00445 | CCC_00470 | CCC_00445 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase NADPH large chain. | 0.633 |
| CCC_00470 | CCC_00469 | CCC_00470 | CCC_00469 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
| CCC_00470 | CCC_02225 | CCC_00470 | CCC_02225 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Glutamate synthase NADPH large chain. | 0.633 |
| CCC_00470 | CCC_02451 | CCC_00470 | CCC_02451 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | O-acetylhomoserine sulfhydrylase / O-succinylhomoserine sulfhydrylase. | 0.542 |
| CCC_00470 | CCC_03497 | CCC_00470 | CCC_03497 | 5 10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Hypothetical protein. | 0.657 |