STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
htpGChaperone Hsp90, heat shock protein C 62.5; Molecular chaperone. Has ATPase activity. (626 aa)    
Predicted Functional Partners:
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
 
 0.986
dnaJ
Heat shock protein (Hsp40), co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent [...]
 
 0.981
ACS38130.1
Molecular chaperone, HSP70 class; Function of strongly homologous gene; factor.
   
 0.973
ACS41179.1
Putative chaperone protein, DnaJ domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor.
  
 0.939
ACS42318.1
Chaperone DnaJ domain protein, putative heat shock protein; Function of strongly homologous gene; factor.
  
 0.939
ACS42858.1
Conserved hypothetical protein, containing N-terminal fragment of heat shock protein DnaJ; Homologs of previously reported genes of unknown function.
  
 0.939
groL
60 kDa chaperonin (protein Cpn60, groEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.936
groL-2
60 kDa chaperonin (protein Cpn60, groEL protein); Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
   
 
 0.936
ACS39682.1
Conserved hypothetical protein; Homologs of previously reported genes of unknown function.
  
 0.933
fbp
Peptidyl-prolyl cis-trans isomerase (Rotamase); Function of homologous gene experimentally demonstrated in an other organism; enzyme.
   
 0.925
Your Current Organism:
Methylorubrum extorquens
NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1
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