node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACS39413.1 | fhcA | MexAM1_META1p1551 | MexAM1_META1p1757 | Putative GXGXG-motif protein, glutamate synthase and formylmethanofuran dehydrogenase-like domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit A; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR. Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. | 0.805 |
ACS39413.1 | fhcB | MexAM1_META1p1551 | MexAM1_META1p1758 | Putative GXGXG-motif protein, glutamate synthase and formylmethanofuran dehydrogenase-like domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit B; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). | 0.774 |
ACS39617.1 | ACS39618.1 | MexAM1_META1p1775 | MexAM1_META1p1776 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | 0.976 |
ACS39617.1 | fae-2 | MexAM1_META1p1775 | MexAM1_META1p1766 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.775 |
ACS39617.1 | fhcA | MexAM1_META1p1775 | MexAM1_META1p1757 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit A; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR. Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. | 0.811 |
ACS39617.1 | fhcB | MexAM1_META1p1775 | MexAM1_META1p1758 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit B; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). | 0.795 |
ACS39617.1 | fhcC | MexAM1_META1p1775 | MexAM1_META1p1755 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit C; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). | 0.789 |
ACS39617.1 | fhcD | MexAM1_META1p1775 | MexAM1_META1p1756 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family. | 0.794 |
ACS39617.1 | mch | MexAM1_META1p1775 | MexAM1_META1p1763 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. | 0.778 |
ACS39617.1 | mtdA | MexAM1_META1p1775 | MexAM1_META1p1728 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency. | 0.773 |
ACS39617.1 | mtdB | MexAM1_META1p1775 | MexAM1_META1p1761 | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. | 0.775 |
ACS39618.1 | ACS39617.1 | MexAM1_META1p1776 | MexAM1_META1p1775 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Orf21. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | 0.976 |
ACS39618.1 | fae-2 | MexAM1_META1p1776 | MexAM1_META1p1766 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formaldehyde-activating enzyme; Catalyzes the condensation of formaldehyde with tetrahydromethanopterin (H(4)MPT) to 5,10- methylenetetrahydromethanopterin, a reaction which also proceeds spontaneously, but at a lower rate than that of the enzyme-catalyzed reaction. Is an essential enzyme for methylotrophic energy metabolism and formaldehyde detoxification of this bacterium. | 0.775 |
ACS39618.1 | fhcA | MexAM1_META1p1776 | MexAM1_META1p1757 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit A; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). May be catalyze the hydrolysis of formylmethanofuran (formyl-MFR) to yield formate and MFR. Belongs to the metallo-dependent hydrolases superfamily. FwdA/FmdA family. | 0.814 |
ACS39618.1 | fhcB | MexAM1_META1p1776 | MexAM1_META1p1758 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit B; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). | 0.798 |
ACS39618.1 | fhcC | MexAM1_META1p1776 | MexAM1_META1p1755 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit C; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the formylmethanofuran (formyl-MFR). | 0.798 |
ACS39618.1 | fhcD | MexAM1_META1p1776 | MexAM1_META1p1756 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | Formyltransferase/hydrolase complex Fhc subunit D; Involved in the transformation of 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) and formate via the intermediate formylmethanofuran (formyl-MFR). Catalyzes the transfer of a formyl group from 5-formyl-H(4)MPT to MFR so as to produce tetrahydromethanopterin (H(4)MPT) and formyl-MFR, which is then hydrolyzed to formate and MFR; Belongs to the FTR family. | 0.798 |
ACS39618.1 | mch | MexAM1_META1p1776 | MexAM1_META1p1763 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase (methenyl-H4MPT cyclohydrolase); Catalyzes the hydrolysis of methenyl-H(4)MPT(+) to 5-formyl- H(4)MPT. | 0.798 |
ACS39618.1 | mtdA | MexAM1_META1p1776 | MexAM1_META1p1728 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | NADP-dependent methylene-tetrahydromethanopterin/methylene- tetrahydrofolate dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. Can also catalyze the reversible dehydrogenation of methylene-H(4)F with 20-fold lower catalytic efficiency. | 0.772 |
ACS39618.1 | mtdB | MexAM1_META1p1776 | MexAM1_META1p1761 | Orf22. Involved in biosynthesis of tetrahydromethanopterin. Essential for formaldehyde oxidation; Function experimentally demonstrated in the studied strain; putative enzyme. | NAD(P)-dependent methylene tetrahydromethanopterin dehydrogenase; Catalyzes the dehydrogenation of methylene-H(4)MPT. | 0.775 |