soxA-2 protein (Methylorubrum extorquens) - STRING interaction network

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Score

soxA-2

Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme. (989 aa)

Predicted Functional Partners:

soxD-2

0.999

soxG-2

0.999

soxB-3

0.998

gcvP

0.997

soxD

0.990

soxG

0.988

glyA

0.976

gcvH

0.969

soxB

0.967

ACS38322.1

0.931

Your Current Organism:

Methylorubrum extorquens

NCBI taxonomy Id: 272630
Other names: M. extorquens AM1, Methylobacterium extorquens AM1, Methylorubrum extorquens AM1, Pseudomonas sp. AM1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACS38322.1	gcvP	MexAM1_META1p0374	MexAM1_META1p0620	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.938
ACS38322.1	glyA	MexAM1_META1p0374	MexAM1_META1p3384	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.914
ACS38322.1	soxA-2	MexAM1_META1p0374	MexAM1_META1p4110	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme.	0.931
ACS38322.1	soxB-3	MexAM1_META1p0374	MexAM1_META1p4108	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Sarcosine oxidase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.904
ACS38322.1	soxD-2	MexAM1_META1p0374	MexAM1_META1p4109	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme.	0.900
ACS38322.1	soxG-2	MexAM1_META1p0374	MexAM1_META1p4111	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	Sarcosine oxidase, gamma subunit; Function of strongly homologous gene; enzyme.	0.900
gcvH	gcvP	MexAM1_META1p0621	MexAM1_META1p0620	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	0.999
gcvH	glyA	MexAM1_META1p0621	MexAM1_META1p3384	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.991
gcvH	soxA-2	MexAM1_META1p0621	MexAM1_META1p4110	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme.	0.969
gcvP	ACS38322.1	MexAM1_META1p0620	MexAM1_META1p0374	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.938
gcvP	gcvH	MexAM1_META1p0620	MexAM1_META1p0621	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.999
gcvP	glyA	MexAM1_META1p0620	MexAM1_META1p3384	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.997
gcvP	soxA-2	MexAM1_META1p0620	MexAM1_META1p4110	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, alpha subunit; Function of strongly homologous gene; enzyme.	0.997
gcvP	soxB-3	MexAM1_META1p0620	MexAM1_META1p4108	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, beta subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme.	0.929
gcvP	soxD	MexAM1_META1p0620	MexAM1_META1p1547	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme.	0.448
gcvP	soxD-2	MexAM1_META1p0620	MexAM1_META1p4109	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, delta subunit; Function of strongly homologous gene; enzyme.	0.942
gcvP	soxG	MexAM1_META1p0620	MexAM1_META1p1545	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, gamma subunit; Function of strongly homologous gene; enzyme.	0.604
gcvP	soxG-2	MexAM1_META1p0620	MexAM1_META1p4111	Glycine dehydrogenase / decarboxylase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.	Sarcosine oxidase, gamma subunit; Function of strongly homologous gene; enzyme.	0.958
glyA	ACS38322.1	MexAM1_META1p3384	MexAM1_META1p0374	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Putative 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (Glycine acetyltransferase); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.914
glyA	gcvH	MexAM1_META1p3384	MexAM1_META1p0621	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.	0.991