node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0004 | ML0603 | gene:17573813 | gene:17574424 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.740 |
ML0004 | dnaN | gene:17573813 | gene:17573811 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.889 |
ML0004 | gyrB | gene:17573813 | gene:17573814 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.763 |
ML0004 | recF | gene:17573813 | gene:17573812 | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | Putative DNA replication and SOS induction protein; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity). | 0.893 |
ML0202 | ML0603 | gene:17574018 | gene:17574424 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.999 |
ML0202 | dnaE | gene:17574018 | gene:17575038 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.998 |
ML0202 | dnaN | gene:17574018 | gene:17573811 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.999 |
ML0202 | dnaZX | gene:17574018 | gene:17576196 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase III, subunit [gamma/tau]; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.998 |
ML0202 | polA | gene:17574018 | gene:17575220 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.960 |
ML0202 | recA | gene:17574018 | gene:17574813 | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.664 |
ML0603 | ML0004 | gene:17574424 | gene:17573813 | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Similar to hypothetical proteins from mycobacteria e.g. M. tuberculosis Rv0004, ypothetical protein, TR:P71573 (EMBL:AL123456) (187 aa); Fasta score E(): 0, 77.2% identity in 167 aa overlap. Previously sequenced as TR:Q50181 (EMBL:Z70722) (199 aa); Fasta score E(): 0, 99.5% identity in 187 aa overlap; Belongs to the UPF0232 family. | 0.740 |
ML0603 | ML0202 | gene:17574424 | gene:17574018 | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Similar to M. tuberculosis Rv3644c, hypothetical protein, TR:O06363 (EMBL:AL123456) (401 aa); Fasta score E(): 0, 84.4% identity in 404 aa overlap. Similar to the N-termini of many DNA polymerase III subunits e.g. Escherichia coli holB, DNA polymerase III, delta' subunit, SW:HOLB_ECOLI (P28631) (334 aa); Fasta score E(): 2.9e-13, 35.1% identity in 205 aa overlap. Previously sequenced as TR:O69546 (EMBL:AL023093) (405 aa); Fasta score E(): 0, 100.0% identity in 405 aa overlap; Similar to the N-terminus of ML2335. | 0.999 |
ML0603 | dnaE | gene:17574424 | gene:17575038 | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | DNA polymerase III, [alpha] subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The alpha chain is the DNA polymerase (By similarity); Belongs to the DNA polymerase type-C family. DnaE subfamily. | 0.998 |
ML0603 | dnaN | gene:17574424 | gene:17573811 | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.998 |
ML0603 | dnaZX | gene:17574424 | gene:17576196 | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | DNA polymerase III, subunit [gamma/tau]; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.998 |
ML0603 | polA | gene:17574424 | gene:17575220 | Putative lipoprotein; Similar to M. tuberculosis Rv2413c, conserved hypothetical protein, TR:P71730 (EMBL:AL123456) (316 aa); Fasta score E(): 0, 83.5% identity in 316 aa overlap. Also similar to Streptomyces coelicolor SCC123.02C, putative DNA-binding protein, TR:Q9RDM2 (EMBL:AL136518) (336 aa); Fasta score E(): 0, 39.3% identity in 326 aa overlap. Previously sequenced as TR:Q49756 (EMBL:U00016) (389 aa); Fasta score E(): 0, 100.0% identity in 371 aa overlap. Contains a possible N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.596 |
dnaA | dnaN | gene:17573810 | gene:17573811 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative DNA polymerase III, [beta] subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for in [...] | 0.997 |
dnaA | gyrB | gene:17573810 | gene:17573814 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.772 |
dnaA | polA | gene:17573810 | gene:17575220 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity. | 0.716 |
dnaA | recA | gene:17573810 | gene:17574813 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity). | 0.730 |