STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0007Putative membrane protein; Similar to M. tuberculosis Rv0007, hypothetical protein, TR:P71575 (EMBL:AL123456) (304 aa); Fasta score E(): 0, 53.8% identity in 316 aa overlap. Previously sequenced as TR:O32870 (EMBL:Z70722) (303 aa); Fasta score E(): 0, 99.7% identity in 303 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Contains a region identical to ML2630. (303 aa)    
Predicted Functional Partners:
ML0256
Putative membrane protein; Similar to M. tuberculosis Rv1024, hypothetical protein, TR:P96376 (EMBL:AL123456) (228 aa); Fasta score E(): 0, 70.5% identity in 220 aa overlap. Contains hydrophobic, possible membrane-spanning region.
  
     0.772
ML2699
Putative secreted protein; Similar to Mycobacterium tuberculosis hypothetical 83.9 kda protein TR:O05436 (EMBL:Z94121) fasta scores: E(): 0, 72.4% in 803 aa. Contains a possible N-terminal signal sequence.
  
     0.765
ML0081
Putative membrane protein; Similar to M. tuberculosis Rv3835c, hypothetical protein, TR:P96243 (EMBL:AL123456) (449 aa); Fasta score E(): 0, 69.4% identity in 457 aa overlap. Contains hydrophobic, possible membrane-spanning region near the N-terminus.
  
     0.752
ML0762
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 16.8 kDa protein RV3258C OR MTV015.03C TR:O53351 (EMBL:AL021840) fasta scores: E(): 0, 76.9% id in 169 aa, and to Streptomyces coelicolor hypothetical 15.0 kDa protein SCE34.11C TR:CAB88914 (EMBL:AL353862) fasta scores: E(): 4.8e-16, 47.0% id in 151 aa.
  
     0.746
ML1560
Conserved hypothetical protein; Highly similar to Mycobacterium tuberculosis hypothetical protein Rv2843 TR:O05816 (EMBL:Z95207) (181 aa); Fasta score E(): 2e-31, 70.2% identity in 168 aa overlap.
  
     0.737
ML0907
Putative conserved membrane protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:O69559 (EMBL:AL022602) (377 aa); Fasta score E(): 0, 100.0% identity in 377 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis TR:O06213 (EMBL:Z95388) (384 aa); Fasta score E(): 0, 62.2% identity in 397 aa overlap(EMBL:Z95388). Contains a possible membrane spanning hydrophobic domain and a possible coiled-coil between residues 155..168.
  
     0.714
aac
Highly similar to several mycobacterial aminoglycoside-resistance determinants e.g. Mycobacterium tuberculosis aminoglycoside 2'-n-acetyltransferase Aac OR RV0262C SW:AAC2_MYCTU (P95219; P72033) fasta scores: E(): 0, 78.7% id in 178 aa.
  
     0.688
gyrA
Putative DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
    0.675
mfd
Putative transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
     0.662
ML2620
Conserved integral membrane protein; Transports trehalose monomycolate (TMM) across the inner membrane; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MmpL subfamily.
  
    0.652
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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