STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rodASimilar to M. tuberculosis ftsW, cell-division protein, SW:FTSW_MYCTU (P71587) (469 aa); Fasta score E(): 0, 82.3% identity in 469 aa overlap and to Streptomyces coelicolor ftsW, cell-division protein, TR:Q9ZBA6 (EMBL:AL109663) (456 aa); Fasta score E(): 3.3e-25, 32.1% identity in 377 aa overlap. Previously sequenced as SW:FTSW_MYCLE (Q50186) (465 aa); Fasta score E(): 0, 99.6% identity in 465 aa overlap. Contains hydrophobic, possible membrane-spanning regions. Contains Pfam match to entry PF01098 FTSW_RODA_SPOVE, Cell cycle protein. Contains PS00428 Cell cycle proteins ftsW / rodA / [...] (465 aa)    
Predicted Functional Partners:
pbpA
Similar to M. tuberculosis pbpA, penicillin-binding protein, TR:P71586 (EMBL:AL123456) (491 aa); Fasta score E(): 0, 85.7% identity in 490 aa overlap. Also similar to Bacillus subtilis penicillin-binding protein 3, pbpC, SW:PBPC_BACSU (P42971) (668 aa); Fasta score E(): 2.8e-15, 24.5% identity in 444 aa overlap. Previously sequenced as TR:Q50185 (EMBL:Z70722) (474 aa); Fasta score E(): 0, 96.4% identity in 472 aa overlap. Contains a probable N-terminal signal sequence. Contains Pfam match to entry PF00905 Transpeptidase, Penicillin binding protein transpeptidase domain; Similar to regi [...]
 
 0.999
pknB
Putative serine/threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.
 
 
 0.983
pknA
Putative serine/threonine protein kinase; Protein kinase that regulates many aspects of mycobacterial physiology. Is a key component of a signal transduction pathway that regulates cell growth, cell shape and cell division via phosphorylation of target proteins.
 
 
 0.980
ML0020
Conserved hypothetical protein; Similar to M. tuberculosis ppp, putative protein phosphatase, TR:P71588 (EMBL:AL123456) (514 aa); Fasta score E(): 0, 76.4% identity in 513 aa overlap and to Streptomyces coelicolor SCH69.15, possible protein phosphatase, TR:Q9XA19 (EMBL:AL079308) (515 aa); Fasta score E(): 0, 40.2% identity in 532 aa overlap. Also similar to many other proteins of undefined function. Previously sequenced as TR:Q50188 (EMBL:Z70722) (509 aa); Fasta score E(): 0, 99.6% identity in 509 aa overlap. Contains hydrophobic, possible membrane-spanning region. Proline-rich C-terminus.
 
  
 0.940
ML0021
Similar to M. tuberculosis Rv0019c, hypothetical protein, TR:P71589 and to Streptomyces coelicolor SCH69.14, hypothetical protein, TR:Q9XA20 (EMBL:AL079308) (172 aa); Fasta score E(): 2e-21, 44.4% identity in 171 aa overlap. Previously sequenced as TR:Q50189 (EMBL:Z70722) (155 aa); Fasta score E(): 0, 100.0% identity in 155 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain; Similar at the C-terminus to ML2076.
 
   
 0.926
murG
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.914
ftsZ
Cell division protein; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.
  
 
 0.914
pbpB
Penicillin-binding protein 2; Identical to the previously sequenced Mycobacterium leprae penicillin binding protein 2 TR:O69558 (EMBL:AL022602) (675 aa); Fasta score E(): 0, 99.9% identity in 675 aa overlap(EMBL:AL022602). Also highly similar to Mycobacterium tuberculosis hypothetical protein TR:O06214 (EMBL:Z95388) (679 aa); Fasta score E(): 0, 80.6% identity in 677 aa overlap(EMBL:Z95388) and to many other penicillin-binding proteins e.g. Neisseria meningitidis SW:PBP2_NEIME (P11882) (581 aa); Fasta score E(): 4.3e-29, 32.4% identity in 590 aa overlap(P11882). Contains Pfam match to [...]
 
 0.911
ML0916
Putative FtsQ-family protein; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.
  
 
 0.882
ML0022
Similar to M. tuberculosis Rv0020c, hypothetical protein, TR:P71590 (EMBL:AL123456) (527 aa); Fasta score E(): 0, 71.9% identity in 531 aa overlap. Previously sequenced as TR:Q50190 (EMBL:Z70722) (463 aa); Fasta score E(): 0, 100.0% identity in 463 aa overlap. Contains Pfam match to entry PF00498 FHA, FHA domain; Similar at the C-terminus to ML2076.
 
   
 0.826
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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