STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
ML0107Putative membrane protein; Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases. Belongs to the glycosyltransferase 85 family. (632 aa)    
Predicted Functional Partners:
embC
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
 
  
 0.994
embA
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
 
  
 0.989
embB
Putative arabinosyl transferase; Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan; Belongs to the emb family.
 
  
 0.972
ML1338
Possible conserved integral membrane protein; Similar to several membrane proteins e.g. Mycobacterium tuberculosis RV2673 TR:P71970 (EMBL:Z80225) (433 aa); Fasta score E(): 0, 82.0% identity in 434 aa overlap and weakly similar to Streptomyces coelicolor TR:Q53873 (EMBL:AL031317) (411 aa); Fasta score E(): 1.1e-12, 28.3% identity in 410 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
   
 0.939
ML0096
Putative membrane protein; Similar to M. tuberculosis Rv3805c, possible membrane protein, TR:O53582 (EMBL:AL123456) (627 aa); Fasta score E(): 0, 80.9% identity in 629 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
   
 0.936
ML0108
Similar To M. tuberculosis Rv3791, putative oxidoreductase, SW:Y1J1_MYCTU (P72057) (254 aa); Fasta score E(): 0, 89.0% identity in 254 aa overlap and to other putative oxidoreductases from the same organism. Shows weaker similarity to Alcaligenes eutrophus phbB, acetoacetyl-CoA reductase, SW:PHBB_ALCEU (P14697) (246 aa); Fasta score E(): 3e-09, 28.3% identity in 191 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature; Shows weak similarity to ML0429 and to the C-terminal half of ML2565.
 
   
 0.929
ML0109
Similar to M. tuberculosis Rv3790, putative oxidoreductase, TR:P72056 (EMBL:AL123456) (461 aa); Fasta score E(): 0, 86.6% identity in 461 aa overlap. Also similar to many bacterial putative oxidoreductases. Contains Pfam match to entry PF01565 FAD_binding_4, FAD binding domain.
 
   
 0.887
ML0110
Possible membrane protein; Required for arabinosylation of arabinogalactan (AG), an essential component of the mycobacterial cell wall. Probably acts as an anchor protein recruiting AftA, the first arabinosyl transferase involved in AG biosynthesis; Belongs to the GtrA family.
 
     0.880
ML2570
Possible integral membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein RV0236C TR:P96419 (EMBL:Z92669) fasta scores: E(): 0, 78.7% id in 1397 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains.
  
   
 0.831
ML1945
Similar to M. tuberculosis conserved hypothetical protein Rv1100 TR:O53448 (EMBL:AL021897) (233 aa); Fasta score E(): 0, 63.8% identity in 257 aa overlap.
  
     0.764
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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