STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0115Conserved hypothetical protein; Interacts with the core proteasome alpha-subunit (PrcA) through its C-terminal hydrophobic-tyrosine-X motif (HbYX motif). Interaction of Bpa with the proteasome stimulates proteosomal peptidase and casein degradation activity, which suggests Bpa could play a role in the removal of non-native or damaged proteins by influencing the conformation of the proteasome complex upon interaction. Belongs to the Bpa family. (174 aa)    
Predicted Functional Partners:
prcA
Proteasome [alpha]-type subunit 1; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1A family.
  
 
 
 0.999
prcB
Proteasome [beta]-type subunit 2; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. Belongs to the peptidase T1B family.
  
 
 
 0.933
ML0114
Similar to M. tuberculosis Rv3781, putative ABC transporter component, TR:P72047 (EMBL:AL123456) (273 aa); Fasta score E(): 0, 91.4% identity in 267 aa overlap. Similar to Yersinia enterocolitica rfbE, O-antigen export system ATP-binding protein, SW:RFBE_YEREN (Q56903) (239 aa); Fasta score E(): 0, 46.9% identity in 224 aa overlap and to other proteins involved in lipopolysaccharide transport. Contains Pfam match to entry PF00005 ABC_tran, ABC transporter. Contains PS00017 ATP/GTP-binding site motif A (P-loop).
     
 0.908
ML0116
Putative membrane protein; Similar to M. tuberculosis Rv3779, unknown membrane protein, TR:P72045 (EMBL:AL123456) (666 aa); Fasta score E(): 0, 66.5% identity in 666 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.817
ML0112
Putative ABC transporter component; Similar to M. tuberculosis Rv3783, integral membrane protein, TR:P72049 (EMBL:AL123456) (280 aa); Fasta score E(): 0, 84.3% identity in 280 aa overlap. Similar to Yersinia enterocolitica rfbD, O-antigen export system permease protein, SW:RFBD_YEREN (Z18920) (259 aa); Fasta score E(): 2.9e-32, 28.2% identity in 259 aa overlap and to other membrane proteins involved in lipopolysaccharide transport. Contains Pfam match to entry PF01061 ABC2_membrane, ABC-2 type transporter.
     
 0.809
rfbE
Similar to M. tuberculosis Rv3782, putative glycosyl transferase, TR:P72048. Shows very weak similarity to proteins involved in lipopolysaccharide biosynthesis.
     
 0.801
ML1316
Probable AAA-family ATPase; ATPase which is responsible for recognizing, binding, unfolding and translocation of pupylated proteins into the bacterial 20S proteasome core particle. May be essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase may function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis.
  
   
 0.778
ML1328
Possible DNA-binding protein; Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side- chain amino group of a substrate lysine.
  
   
 0.693
ML1321
Conserved hypothetical protein; Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.
  
     0.633
ML1706
Conserved hypothetical protein; Highly similar to proteins of undefined function from Streptomyces coelicolor TR:Q9Z586 (EMBL:AL035569) (331 aa); Fasta score E(): 0, 38.6% identity in 337 aa overlap and Mycobacterium tuberculosis RV3015C TR:O53262 (EMBL:AL021287) (337 aa); Fasta score E(): 0, 78.3% identity in 337 aa overlap.
  
   
 0.610
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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