STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0127Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). (229 aa)    
Predicted Functional Partners:
ML0128
Similar to M. tuberculosis Rv2958c, putative glycosyl transferase, TR:P95134 (EMBL:AL123456) (428 aa); Fasta score E(): 0, 75.1% identity in 417 aa overlap and Rv2962c, putative glycosyl transferase, TR:P95130 (EMBL:AL123456) (449 aa); Fasta score E(): 0, 74.4% identity in 425 aa overlap. Similar to Streptomyces venezuelae desVII, glycosyl transferase from a macrolide antibiotic biosynthesis gene cluster, TR:Q9ZGH7 (EMBL:AF079762) (426 aa); Fasta score E(): 1.1e-09, 30.9% identity in 223 aa overlap. Shows similarity to bacterial and eukaryotic glycosyl transferases; Similar to ML0125 a [...]
 
  
 0.931
ML0133
Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family.
  
   
 0.832
mmpL7
Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375.
  
     0.746
ML0042
Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537.
  
     0.732
ML1505
Conserved hypothetical Proline rich protein; Highly similar to Mycobacterium tuberculosis hypothetical protein RV1158C TR:O06556 (EMBL:Z95584) (227 aa); Fasta score E(): 1.1e-16, 51.7% identity in 236 aa overlap. Note the predicted product of this CDS is rich in the amino acids Pro and Ala and displays multiple ProAla repeats.
  
     0.731
ML0047
Similar to M. tuberculosis putative membrane protein e.g. Rv3877, hypothetical protein, TR:O69741 (EMBL:AL123456) (511 aa); Fasta score E(): 0, 74.0% identity in 512 aa overlap. Similarity is weaker to Rv1795, probable membrane protein, TR:O53944 (EMBL:AL123456) (503 aa); Fasta score E(): 2.1e-13, 22.7% identity in 519 aa overlap and Rv0290, hydrophobic protein, TR:O86362 (EMBL:AL123456) (472 aa); Fasta score E(): 2.4e-11, 26.6% identity in 512 aa overlap. Previously sequenced as TR:O33081 (EMBL:Y14967) (480 aa); Fasta score E(): 0, 100.0% identity in 480 aa overlap. Contains hydrophob [...]
  
     0.704
ML0798
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis ATP/GTP binding protein Rv2787 or MTV002.52 TR:O33329 (EMBL:AL008967) fasta scores: E(): 0, 76.5% id in 587 aa and to other M. tuberculosis hypothetical proteins. Contains PS00017 ATP/GTP-binding site motif A (P-loop); C-terminal half is similar to that of ML0048. Also similar to ML1536.
  
     0.692
ML2347
Putative membrane protein; Function unknown. Note the low G+C content of this CDS (46%). Contains a possible membrane spanning hydrophobic domain.
     
 0.686
ML2348
Similar to many proposed glycosyl transferases including: Mycobacterium tuberculosis hypothetical protein Rv1524 SW:YF24_MYCTU (Q50583) (414 aa) fasta scores: E(): 0, 62.6% id in 420 aa, and to Mycobacterium avium rhamnosyltransferase RtfA TR:O69000 (EMBL:AF060183) (428 aa) fasta scores: E(): 0, 55.0% id in 424 aa.
   
  
 0.685
ML0125
Similar to M. tuberculosis Rv2958c, putative glycosyl transferase, TR:P95134 (EMBL:AL123456) (428 aa); Fasta score E(): 0, 74.6% identity in 418 aa overlap and Rv2962c, putative glycosyl transferase, TR:P95130 (EMBL:AL123456) (449 aa); Fasta score E(): 0, 77.5% identity in 426 aa overlap. Similar to Streptomyces venezuelae desVII, glycosyl transferase from a macrolide antibiotic biosynthesis gene cluster, TR:Q9ZGH7 (EMBL:AF079762) (426 aa); Fasta score E(): 1e-09, 30.0% identity in 237 aa overlap. Shows similarity to bacterial and eukaryotic glycosyl transferases; Similar to ML0128 and [...]
  
  
 0.677
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.