STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0129Conserved hypothetical protein; Involved in the reduction of the double bond between C-4 and C-5 during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis. (418 aa)    
Predicted Functional Partners:
ML0130
Conserved hypothetical protein; Catalyzes the methylation of the lipid moiety of the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycoserosates to form phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL).
  
    0.827
inhA
enoyl-[ACP] reductase; Similar to M. tuberculosis inhA Rv1484 SW:INHA_MYCTU (P46533) (269 aa); Fasta score E(): 0, 90.3% identity in 269 aa overlap, and to many others e.g. Escherichia coli enoyl-[acyl-carrier-protein] reductase [NADH] SW:FABI_ECOLI (P29132) (261 aa); Fasta score E(): 1.2e-17, 33.2% identity in 268 aa overlap; Similar to and ML1807.
      
 0.778
ML0131
Putative oxidoreductase; Catalyzes the reduction of the keto moiety of phthiodiolone dimycocerosates (DIM B) and glycosylated phenolphthiodiolone dimycocerosates to form the intermediate compounds phthiotriol and glycosylated phenolphthiotriol dimycocerosates during phthiocerol dimycocerosates (DIM A) and glycosylated phenolphthiocerol dimycocerosates (PGL) biosynthesis.
     
 0.757
ML0065
Similar to putative monooxygenases from M. tuberculosis e.g. Rv3854c, probable monooxygenase, TR:P96223 (EMBL:AL123456) (489 aa); Fasta score E(): 0, 80.1% identity in 488 aa overlap. Others are Rv0892 and Rv1393c. Also similar to the C-terminal half of Deinococcus radiodurans plasmid MP1 DRB0033, putative arylesterase/monoxygenase, TR:Q9RZT0 (EMBL:AE001826) (833 aa); Fasta score E(): 0, 51.5% identity in 480 aa overlap. Shows weaker similarity to Rhodococcus rhodochrous steroid monooxygenase, TR:O50641 (EMBL:AB010439) (549 aa); Fasta score E(): 2e-15, 24.9% identity in 469 aa overlap. [...]
 
   
 0.641
ML2566
Similar to Mycobacterium tuberculosis hypothetical protein RV0241C TR:O53664 (EMBL:AL021929) fasta scores: E(): 0, 81.8% id in 280 aa, and to Streptomyces coelicolor putative dehydratase TR:CAB77291 (EMBL:AL160312) fasta scores: E(): 2.1e-27, 39.5% id in 271 aa. Contains Pfam match to entry PF01575 MaoC_dehydratas, MaoC like domain. Contains PS00211 ABC transporters family signature.
  
    0.606
ML1244
Conserved membrane protein; Highly similar to a family of Mycobacterium tuberculosis proteins e.g. Rv2484c SW:YO84_MYCTU (O53209) (491 aa); Fasta score E(): 0, 75.2% identity in 483 aa overlap. Contains possible membrane spanning hydrophobic domains; Belongs to the long-chain O-acyltransferase family.
  
     0.576
ML1094
Short chain alcohol dehydrogenase; Highly similar to several Mycobacterium tuberculosis putative oxidoreductases e.g. Rv1245c TR:O50460 (EMBL:AL021006) (276 aa); Fasta score E(): 0, 78.3% identity in 277 aa overlap. Also similar to many others including: Pseudomonas paucimobilis SW:LINX_PSEPA (P50198) (250 aa); Fasta score E(): 9.3e-17, 35.6% identity in 194 aa overlap 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature.
  
   
 0.561
ML1470
Conserved membrane protein; Highly similar to Mycobacterium tuberculosis hypothetical protein TR:O53173 (EMBL:AL021246) (123 aa); Fasta score E(): 1.5e-22, 66.7% identity in 108 aa overlap.
       0.493
folC
Highly similar to many folylpolyglutamate synthases (EC 6.3.2.17) including: Lactobacillus casei SW:FOLC_LACCA (P15925) (428 aa); Fasta score E(): 0, 34.1% identity in 437 aa overlap and Mycobacterium tuberculosis RV2447C TR:O53174 (EMBL:AL021246) (487 aa); Fasta score E(): 0, 78.7% identity in 483 aa overlap. Contains Pfam match to entry PF01225 Mur_ligase, Mur ligase family. Contains PS01012 Folylpolyglutamate synthase signature 2.
       0.493
ML1740
Possible short chain reductase; Similar to several including: Thermotoga maritima 3-oxoacyl-[acyl-carrier protein] reductase SW:FABG_THEMA (Q9X248) (246 aa); Fasta score E(): 1.4e-18, 33.2% identity in 193 aa overlap and Mycobacterium tuberculosis possible ketoacyl reductase RV3057C TR:P95101 (EMBL:Z83866) (287 aa); Fasta score E(): 0, 81.8% identity in 280 aa overlap. Contains Pfam match to entry PF00106 adh_short, short chain dehydrogenase. Contains PS00061 Short-chain dehydrogenases/reductases family signature.
  
   
 0.433
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.