node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0042 | ML0127 | gene:17573854 | gene:17573942 | Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537. | Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). | 0.732 |
ML0042 | ML0133 | gene:17573854 | gene:17573948 | Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537. | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | 0.742 |
ML0042 | fadD22 | gene:17573854 | gene:17573949 | Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537. | Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. | 0.610 |
ML0042 | mmpL7 | gene:17573854 | gene:17573952 | Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537. | Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375. | 0.773 |
ML0127 | ML0042 | gene:17573942 | gene:17573854 | Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). | Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537. | 0.732 |
ML0127 | ML0133 | gene:17573942 | gene:17573948 | Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | 0.832 |
ML0127 | fadD22 | gene:17573942 | gene:17573949 | Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). | Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. | 0.494 |
ML0127 | mmpL7 | gene:17573942 | gene:17573952 | Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). | Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375. | 0.746 |
ML0133 | ML0042 | gene:17573948 | gene:17573854 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Putative membrane protein; Similar to M. tuberculosis Rv3882c, conserved hypothetical protein, TR:O05462 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 72.1% identity in 462 aa overlap. Shows weak similarity to M.tuberculosis Rv3885c, hypothetical protein, TR:O05459 (EMBL:AL123456) (537 aa); Fasta score E(): 3.1e-09, 28.0% identity in 382 aa overlap. Previously sequenced as TR:O33077 (EMBL:Y14967) (467 aa); Fasta score E(): 0, 100.0% identity in 467 aa overlap. Contains hydrophobic, possible membrane-spanning regions near the N-terminus; Shows weak similarity to ML1537. | 0.742 |
ML0133 | ML0127 | gene:17573948 | gene:17573942 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Hypothetical protein; Catalyzes the O-methylation of the hydroxyl group located on C-2 of the first rhamnosyl residue linked to the phenolic group of glycosylated phenolphthiocerol dimycocerosates (PGL) and p- hydroxybenzoic acid derivatives (p-HBAD). | 0.832 |
ML0133 | ML0151 | gene:17573948 | gene:17573966 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | 0.813 |
ML0133 | aroF | gene:17573948 | gene:17574337 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.800 |
ML0133 | entC | gene:17573948 | gene:17574633 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Similar to Mycobacterium tuberculosis putative isochorismate synthase entC or Rv3215 or MTCY07D11.11c (372 aa) TR:O05851 (EMBL:Z95120) fasta scores: E(): 0, 73.5% id in 366 aa and to Bacillus subtilis isochorismate synthase dhbC (398 aa) SW:DHBC_BACSU (P45744) fasta scores: E(): 0, 37.9% id in 396 aa. The predicted CDS has an N-terminal extension of approx. 210 aa not present in known isochorismate synthases. Contains Pfam match to entry PF00425 chorismate_bind, chorismate binding enzyme; Similar to ML0236 and ML1269. | 0.904 |
ML0133 | fadD22 | gene:17573948 | gene:17573949 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Putative acyl-CoA synthetase; Similar to M. tuberculosis Rv2948c, acyl-CoA synthase, TR:P96283 (EMBL:AL123456) (705 aa); Fasta score E(): 0, 75.9% identity in 705 aa overlap. Similar to many acyl-CoA synthases e.g. Rhodopseudomonas palustris, badA, benzoate-coenzyme A ligase, TR:Q59760 (EMBL:L42322) (521 aa); Fasta score E(): 0, 31.4% identity in 494 aa overlap. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains Pfam match to entry PF00501 AMP-binding, AMP-binding enzyme; Similar to ML1051, ML1994, ML2257 and ML2546. | 0.933 |
ML0133 | fadD29 | gene:17573948 | gene:17573947 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Similar to several putative acyl-CoA synthases from M. tuberculosis e.g. M. tuberculosis Rv2950c, fadD29, putative acyl-CoA synthase, TR:P95141 (EMBL:AL123456) (619 aa); Fasta score E(): 0, 80.2% identity in 620 aa overlap. Similar to Mycobacterium bovis BCG ORF3, acyl-CoA synthase, TR:P71495 (EMBL:U75685) (582 aa); Fasta score E(): 0, 58.5% identity in 585 aa overlap and to domains of polyketide synthases e.g. Myxococcus xanthus safB, saframycin Mx1 synthetase B, TR:Q50857 (EMBL:U24657) (1770 aa); Fasta score E(): 0, 36.2% identity in 589 aa overlap. Contains Pfam match to entry PF005 [...] | 0.939 |
ML0133 | hisC | gene:17573948 | gene:17575090 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Highly similar to many histidinol-phosphate aminotransferases (EC 2.6.1.9) involved in histidine biosynthesis e.g. Mycobacterium tuberculosis RV1600 TR:SW:HIS8_MYCTU (O06591) (380 aa); Fasta score E(): 0, 83.6% identity in 366 aa overlap and Mycobacterium smegmatis SW:HIS8_MYCSM (P28735) (219 aa); Fasta score E(): 0, 77.2% identity in 219 aa overlap. Contains Pfam match to entry PF00222 aminotran_2, Aminotransferases class-II. | 0.800 |
ML0133 | mmpL7 | gene:17573948 | gene:17573952 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Putative membrane protein; Similar to members of the M. tuberculosis mmpL family of membrane proteins e.g. Rv2942, mmpL7, putative membrane protein, SW:MML7_MYCTU (P96289) (920 aa); Fasta score E(): 0, 68.6% identity in 881 aa overlap. Contains hydrophobic, possible membrane-spanning regions; Similar to ML1231 and ML2378. Similar to pseudogene ML2375. | 0.735 |
ML0133 | trpE | gene:17573948 | gene:17575101 | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] | 0.810 |
ML0151 | ML0133 | gene:17573966 | gene:17573948 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Conserved hypothetical protein; Removes the pyruvyl group from chorismate to provide 4- hydroxybenzoate (4HB). Involved in the synthesis of glycosylated p- hydroxybenzoic acid methyl esters (p-HBADs) and phenolic glycolipids (PGL) that play important roles in the pathogenesis of mycobacterial infections (By similarity); Belongs to the chorismate pyruvate-lyase type 2 family. | 0.813 |
ML0151 | aroF | gene:17573966 | gene:17574337 | Similar to M. tuberculosis Rv0948c, hypothetical protein, SW:Y948_MYCTU (P71562) (105 aa); Fasta score E(): 1.9e-32, 83.8% identity in 105 aa overlap. Also similar to Streptomyces coelicolor SCD63.16C, hypothetical protein, TR:CAB82023 (EMBL:AL161755) (110 aa); Fasta score E(): 3.9e-06, 44.4% identity in 72 aa overlap. | Putative chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. | 0.962 |