STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
lsr2Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] (112 aa)    
Predicted Functional Partners:
mihF
Putative integration host factor; Similar to M. tuberculosis mihF, Rv1388, possible integration host factor, TR:P71658 (EMBL:AL123456) (190 aa); Fasta score E(): 0, 98.1% identity in 105 aa overlap. Similar to Mycobacterium smegmatis mihF, integration host factor, TR:P96802 (EMBL:U75344) (105 aa); Fasta score E(): 7.5e-32, 94.1% identity in 102 aa overlap.
  
   
 0.858
ML0542
Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity).
      
 0.842
mrsA
Putative phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
      
 0.805
ML1683
Probable histone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions.
      
 0.798
cysS2
cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily.
      
 0.797
ML0229
Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap.
 
     0.707
pknG
Similar to M. tuberculosis pknG, Rv0410c, putative serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa overlap. Similar to many bacterial putative serine/threonine protein kinases e.g. Streptomyces coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% identity in 793 aa overlap. Similar in part, to protein kinases from Myxococcus xanthus e.g. pkn12, serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 aa o [...]
      
 0.689
clpC
Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...]
       0.677
panC
Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family.
       0.668
panD
Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine.
       0.668
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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