node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0229 | lsr2 | gene:17574046 | gene:17574051 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | 0.707 |
ML0229 | panC | gene:17574046 | gene:17574047 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Putative pantoate-[beta]-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. | 0.976 |
ML0229 | panD | gene:17574046 | gene:17574048 | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.877 |
ML0542 | cysS2 | gene:17574363 | gene:17575136 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.828 |
ML0542 | lsr2 | gene:17574363 | gene:17574051 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | 0.842 |
ML0542 | mihF | gene:17574363 | gene:17574361 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Putative integration host factor; Similar to M. tuberculosis mihF, Rv1388, possible integration host factor, TR:P71658 (EMBL:AL123456) (190 aa); Fasta score E(): 0, 98.1% identity in 105 aa overlap. Similar to Mycobacterium smegmatis mihF, integration host factor, TR:P96802 (EMBL:U75344) (105 aa); Fasta score E(): 7.5e-32, 94.1% identity in 102 aa overlap. | 0.941 |
ML0542 | mrsA | gene:17574363 | gene:17574185 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Putative phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.845 |
ML0542 | pknG | gene:17574363 | gene:17574123 | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | Similar to M. tuberculosis pknG, Rv0410c, putative serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa overlap. Similar to many bacterial putative serine/threonine protein kinases e.g. Streptomyces coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% identity in 793 aa overlap. Similar in part, to protein kinases from Myxococcus xanthus e.g. pkn12, serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 aa o [...] | 0.645 |
ML1683 | lsr2 | gene:17575526 | gene:17574051 | Probable histone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | 0.798 |
ML1683 | mihF | gene:17575526 | gene:17574361 | Probable histone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | Putative integration host factor; Similar to M. tuberculosis mihF, Rv1388, possible integration host factor, TR:P71658 (EMBL:AL123456) (190 aa); Fasta score E(): 0, 98.1% identity in 105 aa overlap. Similar to Mycobacterium smegmatis mihF, integration host factor, TR:P96802 (EMBL:U75344) (105 aa); Fasta score E(): 7.5e-32, 94.1% identity in 102 aa overlap. | 0.450 |
clpC | lsr2 | gene:17574052 | gene:17574051 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | 0.677 |
clpC | panD | gene:17574052 | gene:17574048 | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | Putative aspartate-1-decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. | 0.826 |
cysS2 | ML0542 | gene:17575136 | gene:17574363 | cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.828 |
cysS2 | lsr2 | gene:17575136 | gene:17574051 | cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | 0.797 |
cysS2 | mrsA | gene:17575136 | gene:17574185 | cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | Putative phosphoglucomutase/phosphomannomutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.818 |
cysS2 | pknG | gene:17575136 | gene:17574123 | cysteinyl-tRNA synthase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | Similar to M. tuberculosis pknG, Rv0410c, putative serine/threonine protein kinase, TR:P96256 (EMBL:AL123456) (750 aa); Fasta score E(): 0, 83.1% identity in 756 aa overlap. Similar to many bacterial putative serine/threonine protein kinases e.g. Streptomyces coelicolor SC6D10.09, possible protein kinase, TR:CAB71204 (EMBL:AL138538) (903 aa); Fasta score E(): 0, 42.0% identity in 793 aa overlap. Similar in part, to protein kinases from Myxococcus xanthus e.g. pkn12, serine/threonine protein kinase, TR:Q9XBP5 (EMBL:AF159692) (465 aa); Fasta score E(): 2.9e-10, 28.4% identity in 292 aa o [...] | 0.621 |
lsr2 | ML0229 | gene:17574051 | gene:17574046 | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | Similar to M. tuberculosis Rv3603c, hypothetical protein, TR:O06279 (EMBL:AL123456) (303 aa); Fasta score E(): 0, 67.8% identity in 311 aa overlap. Similar to the N-terminal half of Streptomyces coelicolor SCE126.02C, hypothetical protein, TR:Q9X845 (EMBL:AL049630) (420 aa); Fasta score E(): 4.1e-24, 36.7% identity in 294 aa overlap. Previously sequenced as TR:O69525 (EMBL:AL023093) (309 aa); Fasta score E(): 0, 100.0% identity in 309 aa overlap. | 0.707 |
lsr2 | ML0542 | gene:17574051 | gene:17574363 | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | Conserved hypothetical protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity). | 0.842 |
lsr2 | ML1683 | gene:17574051 | gene:17575526 | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | Probable histone-like protein; Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. | 0.798 |
lsr2 | clpC | gene:17574051 | gene:17574052 | Lsr2 protein (15 kDa antigen); DNA-bridging protein that has both architectural and regulatory roles. Influences the organization of chromatin and gene expression by binding non-specifically to DNA, with a preference for AT-rich sequences, and bridging distant DNA segments. Represses expression of multiple genes involved in a broad range of cellular processes. May coordinate global gene regulation and virulence as well as genes important for adaptation to changing O(2) levels. Protects against reactive oxygen intermediates (By similarity). Dominant T-cell antigen and stimulates lymphop [...] | Similar to M. tuberculosis clpC, ATP-dependent Clp protease, SW:CLPC_MYCTU (O06286) (848 aa); Fasta score E(): 0, 97.2% identity in 845 aa overlap. Similar to many e.g. Bacillus subtilis clpC, negative regulator of genetic competence (clpC-family) and Treponema hyodysenteriae tlyB, hemolysin B, SW:HLYB_TREHY (Q54316) (828 aa); Fasta score E(): 0, 51.4% identity in 812 aa overlap. Contains Pfam match to entry PF00495 clpA_B, Chaperonin clpA/B. Contains Pfam match to entry PF02151 UVR, UvrB/uvrC motif. Contains 2 x PS00017 ATP/GTP-binding site motif A (P-loop); Similar to ML2490; Belongs [...] | 0.677 |