node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ML0258 | ML0475 | gene:17574076 | gene:17574296 | Hypothetical protein; Similar to M. tuberculosis Rv1026, hypothetical protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score E(): 0, 77.6% identity in 321 aa overlap. Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of Escherichia coli ppx, exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta score E(): 6.8e-07, 25.3% identity in 297 aa overlap; Shows weak similarity to ML2434. | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.586 |
ML0258 | ML2434 | gene:17574076 | gene:17576297 | Hypothetical protein; Similar to M. tuberculosis Rv1026, hypothetical protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score E(): 0, 77.6% identity in 321 aa overlap. Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of Escherichia coli ppx, exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta score E(): 6.8e-07, 25.3% identity in 297 aa overlap; Shows weak similarity to ML2434. | Conserved hypothetical protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.980 |
ML0450 | ML0474 | gene:17574271 | gene:17574295 | Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.999 |
ML0450 | ML0475 | gene:17574271 | gene:17574296 | Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.629 |
ML0474 | ML0450 | gene:17574295 | gene:17574271 | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.999 |
ML0474 | ML0475 | gene:17574295 | gene:17574296 | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.774 |
ML0475 | ML0258 | gene:17574296 | gene:17574076 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Hypothetical protein; Similar to M. tuberculosis Rv1026, hypothetical protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score E(): 0, 77.6% identity in 321 aa overlap. Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of Escherichia coli ppx, exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta score E(): 6.8e-07, 25.3% identity in 297 aa overlap; Shows weak similarity to ML2434. | 0.586 |
ML0475 | ML0450 | gene:17574296 | gene:17574271 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. | 0.629 |
ML0475 | ML0474 | gene:17574296 | gene:17574295 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. | 0.774 |
ML0475 | ML1359 | gene:17574296 | gene:17575197 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.558 |
ML0475 | ML2434 | gene:17574296 | gene:17576297 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Conserved hypothetical protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | 0.582 |
ML0475 | aspS | gene:17574296 | gene:17574322 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | 0.522 |
ML0475 | gltB | gene:17574296 | gene:17573873 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Similar to M. tuberculosis Rv3859c, putative ferredoxin-dependent glutamate synthase, TR:P96218 (EMBL:Al123456) (1527 aa); Fasta score E(): 0, 90.2% identity in 1527 aa overlap and to Synechocystis sp. gltB, ferredoxin-dependent glutamate synthase 1, SW:GLTB_SYNY3 (P55037) (1550 aa); Fasta score E(): 0, 57.2% identity in 1525 aa overlap. Contains Pfam match to entry PF01493 DUF14, Domain of unknown function. Contains Pfam match to entry PF01645 Glu_synthase, Conserved region in glutamate synthase. Contains PS00095 C-5 cytosine-specific DNA methylases C-terminal signature. | 0.566 |
ML0475 | rplQ | gene:17574296 | gene:17575808 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | Similar to M. tuberculosis 50S ribosomal protein L17 rplQ Rv3456c SW:RL17_MYCTU (O06323) (180 aa); Fasta score E(): 0, 81.9% identity in 171 aa overlap. Contains Pfam match to entry PF01196 Ribosomal_L17, Ribosomal protein L17. | 0.485 |
ML0475 | rplS | gene:17574296 | gene:17575454 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. | 0.541 |
ML0475 | rpsA | gene:17574296 | gene:17575221 | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 30S ribosomal protein S1; Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity). | 0.485 |
ML1359 | ML0475 | gene:17575197 | gene:17574296 | Conserved hypothetical protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.558 |
ML2434 | ML0258 | gene:17576297 | gene:17574076 | Conserved hypothetical protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Hypothetical protein; Similar to M. tuberculosis Rv1026, hypothetical protein, TR:P96374 (EMBL:AL123456) (319 aa); Fasta score E(): 0, 77.6% identity in 321 aa overlap. Similar to many bacterial hypothetical proteins and shows weak similarity to N-terminal half of Escherichia coli ppx, exopolyphosphatase, SW:PPX_ECOLI (P29014) (512 aa); Fasta score E(): 6.8e-07, 25.3% identity in 297 aa overlap; Shows weak similarity to ML2434. | 0.980 |
ML2434 | ML0475 | gene:17576297 | gene:17574296 | Conserved hypothetical protein; Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain. | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.582 |
aspS | ML0475 | gene:17574322 | gene:17574296 | aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. | Similar to M. tuberculosis Rv2603c, conserved hypothetical protein, SW:YQ03_MYCTU (O33214) (251 aa); Fasta score E(): 0, 92.4% identity in 251 aa overlap. Similar to many bacterial hypothetical proteins. Previously sequenced as SW:YQ03_MYCLE (Q49645) (251 aa); Fasta score E(): 0, 100.0% identity in 251 aa overlap. Contains Pfam match to entry PF01709 DUF28, Domain of unknown function. | 0.522 |