STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
priAPutative primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (651 aa)    
Predicted Functional Partners:
ssb
Similar to Escherichia coli single-strand binding protein SW:SSB_ECOLI (P02339) fasta scores: E(): 1.4e-09, 32.6% in 172 aa, and to Mycobacterium tuberculosis single-strand binding protein SW:SSB_MYCTU (P71711) fasta scores: E(): 0, 89.3% in 168 aa. Contains Pfam match to entry PF00436 SSB, Single-strand binding protein family.
    
 
 0.778
ML2687
Conserved membrane protein; Similar to Mycobacterium tuberculosis hypothetical 61.2 kda protein cy21d4.14 TR:P71708 (EMBL:Z80775) fasta scores: E(): 0, 78.7% in 531 aa, and to Streptomyces coelicolor hypothetical 44.5 kda protein TR:Q9X7Z2 (EMBL:AL049497) fasta scores: E(): 1.1e-06, 29.6% in 416 aa. Contains multiple possible membrane spanning hydrophobic domains.
  
     0.679
dnaB
Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity.
 
 
 0.636
ML0159
Putative membrane protein; Similar to M. tuberculosis Rv0955, possible membrane protein, SW:Y955_MYCTU (P71555) (455 aa); Fasta score E(): 0, 75.9% identity in 419 aa overlap. Previously sequenced as TR:Q9Z5H7 (EMBL:AL035500) (430 aa); Fasta score E(): 0, 99.8% identity in 430 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
     0.634
ML0228
Putative membrane protein; Similar to M. tuberculosis Rv3604c, putative membrane protein, TR:O06278 (EMBL:AL123456) (462 aa); Fasta score E(): 0, 59.7% identity in 432 aa overlap. Previously sequenced as TR:O69526 (EMBL:AL023093) (432 aa); Fasta score E(): 0, 100.0% identity in 432 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
     0.596
ML0565
Putative transcriptional regulator; Involved in cell division and chromosome segregation.
 
     0.596
fmt
Putative methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family.
  
    0.594
ML2570
Possible integral membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein RV0236C TR:P96419 (EMBL:Z92669) fasta scores: E(): 0, 78.7% id in 1397 aa. Contains a possible N-terminal signal sequence and multiple possible membrane spanning hydrophobic domains.
  
     0.589
dfp
Putative flavoprotein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family.
  
    0.560
ML1504
Probable conserved membrane protein; Highly similar to several proteins of undefined function e.g. Mycobacterium tuberculosis possible membrane protein RV1159 TR:O06557 (EMBL:Z95584) (431 aa); Fasta score E(): 0, 75.7% identity in 420 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
     0.548
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.