STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
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[Homology]
Score
lprGPutative lipoprotein; Probably helps membrane protein ML0556 (P55) transport triacylglycerides (TAG) across the inner cell membrane into the periplasm and probably ultimately to the outer membrane. TAG probably regulates lipid metabolism and growth regulation. Binds di- and triacylated phosphatidyl-myo-inositol mannosides (PIMs), and glycolipid lipoglycan modulins lipoarabinomannan (LAM) and lipomannan (LM), facilitating their recognition by TLR2. Required for activity of drug efflux transporter ML0556. Required, probably with ML0556, for normal surface localization of LAM. (238 aa)    
Predicted Functional Partners:
ML0556
Putative integral membrane drug transport protein; In association with lipoprotein LprG probably transports triacylglycerides (TAG) across the inner cell membrane into the periplasm; TAG probably regulates lipid metabolism and growth regulation. May be an efflux transporter and involved in maintaining correct cell wall permeability. Probably required with LprG for normal surface localization of lipoarabinomannan (LAM). Belongs to the major facilitator superfamily.
 
   
 0.961
ML2529
Conserved membrane protein; Similar to Mycobacterium tuberculosis hypothetical protein RV0290 TR:O86362 (EMBL:AL021930) fasta scores: E(): 0, 76.4% id in 471 aa, and to Streptomyces coelicolor putative integral membrane protein SC3C3.21 TR:O86654 (EMBL:AL031231) fasta scores: E(): 1.9e-05, 23.8% id in 483 aa. Contains multiple possible membrane spanning hydrophobic domains towards the C-terminus.
  
     0.735
ribC
Similar to M. tuberculosis ribC, Rv1412, riboflavin synthase [alpha] chain, SW:RISA_MYCTU (P71680) (201 aa); Fasta score E(): 0, 82.4% identity in 199 aa overlap. Similar to many e.g. Bacillus subtilis ribE, riboflavin synthase alpha chain, SW:RISA_BACSU (P16440) (215 aa); Fasta score E(): 9.5e-28, 43.4% identity in 198 aa overlap. Contains 2 Pfam matches to entry PF00677 Lum_binding, Lumazine binding domain. Contains 2 x PS00693 Riboflavin synthase alpha chain family signature.
       0.734
ML1030
Conserved hypothetical protein; Identical to the previously sequenced Mycobacterium leprae hypothetical protein TR:Q49994 (EMBL:U15181) (232 aa); Fasta score E(): 0, 99.6% identity in 232 aa overlap. Also highly similar to Mycobacterium tuberculosis hypothetical protein Rv2695 TR:O07197 (EMBL:Z96072) (235 aa); Fasta score E(): 0, 76.5% identity in 230 aa overlap.
  
     0.720
ML0383
Similar to M. tuberculosis Rv3415c, conserved hypothetical protein, TR:Q50711 (EMBL:AL123456) (275 aa); Fasta score E(): 0, 73.6% identity in 277 aa overlap. Previously sequenced as TR:Q49858 (EMBL:U00020) (264 aa); Fasta score E(): 0, 99.6% identity in 263 aa overlap.
  
     0.697
lpqH
Possible lipoprotein; Similar to M. tuberculosis 19 kDa lipoprotein antigen precursor lpqH Rv3763. Contains a possible N-terminal signal sequence and a PS00013 Prokaryotic membrane lipoprotein lipid attachment site.
      
 0.682
ML0185
Putative membrane protein; Similar to M.tuberculosis Rv0996, hypothetical protein, TR:O05579 (EMBL:AL123456) (358 aa); Fasta score E(): 0, 66.4% identity in 360 aa overlap. Previously sequenced as TR:Q9Z5F8 (EMBL:AL035500) (342 aa); Fasta score E(): 0, 100.0% identity in 342 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
  
     0.652
ML0806
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 14.3 kDa protein Rv3217c or MTCY07D11.09 TR:O05849 (EMBL:Z95120) fasta scores: E(): 0, 77.1% id in 140 aa. Contains hydrophobic, possible membrane-spanning regions.
  
     0.652
ML2113
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 15.8 kda protein TR:O05902 (EMBL:Z95210) fasta scores: E(): 0, 83.9% in 143 aa, and to Mycobacterium tuberculosis hypothetical 15.3 kda protein Rv1546 SW:YF46_MYCTU (Q10780) fasta scores: E(): 1e-19, 38.0% in 142 aa.
  
     0.643
ML1539
Probable membrane protein; Similar to several Mycobacterium tuberculosis proteins of undefined function e.g. putative membrane protein RV1795 TR:O53944 (EMBL:AL022021) (503 aa); Fasta score E(): 0, 76.9% identity in 503 aa overlap. Contains multiple possible membrane spanning hydrophobic domains.
  
    0.626
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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