STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0564Conserved hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (359 aa)    
Predicted Functional Partners:
ML0565
Putative transcriptional regulator; Involved in cell division and chromosome segregation.
 
  
 0.939
ML0563
Conserved hypothetical protein; Displays ATPase and GTPase activities.
  
  
 0.937
uvrC
Putative excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
       0.859
ribA
Putative GTP cyclohydrolase II/3,4-dihydroxy-2-butanone-4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
       0.675
ribH
6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin; Belongs to the DMRL synthase family.
       0.675
ML0561
Putative membrane protein; Similar to M. tuberculosis Rv1417, hypothetical protein, SW:YE17_MYCTU (P71686) (154 aa); Fasta score E(): 0, 75.5% identity in 143 aa overlap. Similar to other hypothetical proteins e.g. Corynebacterium ammoniagenes ribX, hypothetical protein, TR:O24754 (EMBL:AB003693) (184 aa); Fasta score E(): 2.1e-15, 34.5% identity in 148 aa overlap. Contains hydrophobic, possible membrane-spanning regions.
       0.675
ML0020
Conserved hypothetical protein; Similar to M. tuberculosis ppp, putative protein phosphatase, TR:P71588 (EMBL:AL123456) (514 aa); Fasta score E(): 0, 76.4% identity in 513 aa overlap and to Streptomyces coelicolor SCH69.15, possible protein phosphatase, TR:Q9XA19 (EMBL:AL079308) (515 aa); Fasta score E(): 0, 40.2% identity in 532 aa overlap. Also similar to many other proteins of undefined function. Previously sequenced as TR:Q50188 (EMBL:Z70722) (509 aa); Fasta score E(): 0, 99.6% identity in 509 aa overlap. Contains hydrophobic, possible membrane-spanning region. Proline-rich C-terminus.
  
  
 0.520
ML0758
Putative oxidoreductase; Bifunctional enzyme that catalyzes the GTP-dependent successive addition of multiple gamma-linked L-glutamates to the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form polyglutamated F420 derivatives, and the FMNH2- dependent reduction of dehydro-F420-0 to form F420-0. In the N-terminal section; belongs to the CofE family.
  
  
 0.501
ML0592
Putative DNA-binding protein; Similar to M. tuberculosis Rv1460, hypothetical protein, TR:O53151 (EMBL:AL123456) (278 aa); Fasta score E(): 0, 79.6% identity in 250 aa overlap. Similar to other bacterial hypothetical proteins e.g. Streptomyces coelicolor SCC22.08C, putative DNA-binding protein, TR:Q9XAD0 (EMBL:AL096839) (252 aa); Fasta score E(): 5.6e-30, 45.4% identity in 216 aa overlap. Previously sequenced as TR:Q49688 (EMBL:U00013) (254 aa); Fasta score E(): 0, 99.6% identity in 254 aa overlap. Contains a probable helix-turn-helix motif at aa 215-236 (Score 1054, SD +2.78).
  
     0.499
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
     0.407
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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