STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metAPutative homoserine o-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (382 aa)    
Predicted Functional Partners:
metZ
Putative o-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
 
  
 0.953
hom
Homoserine dehydrogenase; Identical to the previously sequenced Mycobacterium leprae homoserine dehydrogenase (EC 1.1.1.3) SW:DHOM_MYCLE (P46806) (441 aa); Fasta score E(): 0, 99.8% identity in 441 aa overlap. Also highly similar to orthologues from Mycobacterium tuberculosis SW:DHOM_MYCTU (Q10601) (441 aa); Fasta score E(): 0, 89.5% identity in 438 aa overlap and Corynebacterium glutamicum SW:DHOM_CORGL (P08499) (445 aa); Fasta score E(): 0, 60.3% identity in 431 aa overlap. Contains Pfam match to entry PF00742 Homoserine_dh, Homoserine dehydrogenase. Contains Pfam match to entry PF01 [...]
 
 
 0.951
metB
Cystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity).
    
 0.941
cysM2
Similar to Prokaryotic and Eukaryotic cystathionine beta-synthases including: Mycobacterium tuberculosis Rv1077 TR:O53425 (EMBL:AL021897) (464 aa) fasta scores: E(): 0, 90.1% id in 464 aa and Homo sapiens SW:CBS_HUMAN (550 aa) fasta scores: E(): 0, 39.5% id in 479 aa. Contains 2 Pfam matches to entry PF00571 CBS, CBS domain. Contains Pfam match to entry PF00291 S_T_dehydratase, Pyridoxal-phosphate dependent enzyme; Similar to ML0839.
  
 
 0.845
ilvA
Threonine deaminase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA (By similarity).
  
 
 0.823
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.816
ML1727
Similar in the C-terminus to many phosphoserine phosphatases (EC 3.1.3.3) including: Escherichia coli SW:SERB_ECOLI (P06862) (322 aa); Fasta score E(): 1.7e-29, 38.5% identity in 309 aa overlap and Mycobacterium tuberculosis RV3042C TR:O53289 (EMBL:AL021287) (409 aa); Fasta score E(): 0, 86.3% identity in 408 aa overlap. Contains Pfam match to entry PF00702 Hydrolase, haloacid dehalogenase-like hydrolase.
   
 
  0.801
pssA
Similar to M. tuberculosis pssA, Rv0436c, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_MYCTU (P96282) (286 aa); Fasta score E(): 0, 77.9% identity in 285 aa overlap. Similar to many e.g. Helicobacter pylori pssA, CDP-diacylglycerol-serine o-phosphatidyltransferase, SW:PSS_HELPY (Q48269) (237 aa); Fasta score E(): 2.3e-14, 34.6% identity in 234 aa overlap. Previously sequenced as TR:Q9ZBM2 (EMBL:AL035159) (300 aa); Fasta score E(): 0, 100.0% identity in 300 aa overlap. Contains Pfam match to entry PF01066 CDP-OH_P_transf, CDP-alcohol phosphatidyltransferase. Contains PS00 [...]
     
  0.800
trpB
Tryptophan synthase [beta] chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.800
trpA
Tryptophan synthase [alpha] chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.800
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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