Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ML0175 | ML0397 | gene:17573990 | gene:17574216 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Putative transporter protein; C-terminal half is similar to sugar permeases e.g. Escherichia coli AraH, L-arabinose transport system permease protein, SW:ARAH_ECOLI (P08532) (329 aa); Fasta score E(): 1.1e-26, 36.0% identity in 297 aa overlap. The N-terminal half shows weak similarity to other proteins containing PAS and DUF9 domains. There is a possiblity that this is a signal transduction protein. Previously sequenced as TR:Q49739 (EMBL:U00015) (577 aa); Fasta score E(): 0, 99.8% identity in 577 aa overlap. Contains hydrophobic, possible membrane-spanning regions in the C-terminal ha [...] | 0.405 |
| ML0175 | ML2124 | gene:17573990 | gene:17575977 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.555 |
| ML0175 | ML2440 | gene:17573990 | gene:17576303 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable). | 0.438 |
| ML0175 | mtrA | gene:17573990 | gene:17574597 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.854 |
| ML0175 | mtrB | gene:17573990 | gene:17574598 | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | Putative two-component system sensor kinase; Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity). | 0.407 |
| ML0397 | ML0175 | gene:17574216 | gene:17573990 | Putative transporter protein; C-terminal half is similar to sugar permeases e.g. Escherichia coli AraH, L-arabinose transport system permease protein, SW:ARAH_ECOLI (P08532) (329 aa); Fasta score E(): 1.1e-26, 36.0% identity in 297 aa overlap. The N-terminal half shows weak similarity to other proteins containing PAS and DUF9 domains. There is a possiblity that this is a signal transduction protein. Previously sequenced as TR:Q49739 (EMBL:U00015) (577 aa); Fasta score E(): 0, 99.8% identity in 577 aa overlap. Contains hydrophobic, possible membrane-spanning regions in the C-terminal ha [...] | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | 0.405 |
| ML0397 | ML2124 | gene:17574216 | gene:17575977 | Putative transporter protein; C-terminal half is similar to sugar permeases e.g. Escherichia coli AraH, L-arabinose transport system permease protein, SW:ARAH_ECOLI (P08532) (329 aa); Fasta score E(): 1.1e-26, 36.0% identity in 297 aa overlap. The N-terminal half shows weak similarity to other proteins containing PAS and DUF9 domains. There is a possiblity that this is a signal transduction protein. Previously sequenced as TR:Q49739 (EMBL:U00015) (577 aa); Fasta score E(): 0, 99.8% identity in 577 aa overlap. Contains hydrophobic, possible membrane-spanning regions in the C-terminal ha [...] | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.548 |
| ML0397 | mtrA | gene:17574216 | gene:17574597 | Putative transporter protein; C-terminal half is similar to sugar permeases e.g. Escherichia coli AraH, L-arabinose transport system permease protein, SW:ARAH_ECOLI (P08532) (329 aa); Fasta score E(): 1.1e-26, 36.0% identity in 297 aa overlap. The N-terminal half shows weak similarity to other proteins containing PAS and DUF9 domains. There is a possiblity that this is a signal transduction protein. Previously sequenced as TR:Q49739 (EMBL:U00015) (577 aa); Fasta score E(): 0, 99.8% identity in 577 aa overlap. Contains hydrophobic, possible membrane-spanning regions in the C-terminal ha [...] | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.551 |
| ML1439 | mtrA | gene:17575277 | gene:17574597 | Conserved hypothetical protein; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters. Belongs to the RNA polymerase-binding protein RbpA family. | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.522 |
| ML2124 | ML0175 | gene:17575977 | gene:17573990 | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | 0.555 |
| ML2124 | ML0397 | gene:17575977 | gene:17574216 | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | Putative transporter protein; C-terminal half is similar to sugar permeases e.g. Escherichia coli AraH, L-arabinose transport system permease protein, SW:ARAH_ECOLI (P08532) (329 aa); Fasta score E(): 1.1e-26, 36.0% identity in 297 aa overlap. The N-terminal half shows weak similarity to other proteins containing PAS and DUF9 domains. There is a possiblity that this is a signal transduction protein. Previously sequenced as TR:Q49739 (EMBL:U00015) (577 aa); Fasta score E(): 0, 99.8% identity in 577 aa overlap. Contains hydrophobic, possible membrane-spanning regions in the C-terminal ha [...] | 0.548 |
| ML2124 | ML2440 | gene:17575977 | gene:17576303 | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable). | 0.479 |
| ML2124 | lpqB | gene:17575977 | gene:17574599 | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | Putative lipoprotein; Similar to Mycobacterium tuberculosis putative lipoprotein RV3244C OR MTCY20B11.19C TR:O05889 (EMBL:Z95121) fasta scores: E(): 0, 87.9% id in 579 aa, and to Streptomyces coelicolor putative lipoprotein SCE33.13C TR:CAB90922 (EMBL:AL355774) fasta scores: E(): 0.00039, 24.4% id in 624 aa. Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | 0.630 |
| ML2124 | mtrA | gene:17575977 | gene:17574597 | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.962 |
| ML2124 | mtrB | gene:17575977 | gene:17574598 | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | Putative two-component system sensor kinase; Member of the two-component regulatory system MtrA/MtrB. Seems to function as a membrane-associated protein kinase that phosphorylates MtrA in response to environmental signals (By similarity). | 0.460 |
| ML2440 | ML0175 | gene:17576303 | gene:17573990 | Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable). | Putative two-component system sensor kinase; Member of the two-component regulatory system MprB/MprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to environmental signals MprB acts as both a membrane-associated protein kinase that undergoes autophosphorylation and subsequently transfers the phosphate to MprA, and a protein phosphatase that dephosphorylates phospho-MprA (By similarity). | 0.438 |
| ML2440 | ML2124 | gene:17576303 | gene:17575977 | Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable). | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.479 |
| ML2440 | mtrA | gene:17576303 | gene:17574597 | Probable two-component system sensor histidine kinase; Probably forms part of a two-component regulatory system SenX3/RegX3. Phosphorylates RegX3 (Probable). | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.944 |
| dnaA | mtrA | gene:17573810 | gene:17574597 | Putative chromosomal replication initiator protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity). | Putative two-component response regulator; Member of the two-component regulatory system MtrA/MtrB. | 0.530 |
| lpqB | ML2124 | gene:17574599 | gene:17575977 | Putative lipoprotein; Similar to Mycobacterium tuberculosis putative lipoprotein RV3244C OR MTCY20B11.19C TR:O05889 (EMBL:Z95121) fasta scores: E(): 0, 87.9% id in 579 aa, and to Streptomyces coelicolor putative lipoprotein SCE33.13C TR:CAB90922 (EMBL:AL355774) fasta scores: E(): 0.00039, 24.4% id in 624 aa. Contains a probable N-terminal signal sequence. Contains PS00013 Prokaryotic membrane lipoprotein lipid attachment site. | Sensor histidine kinase; Member of the two-component regulatory system PrrB/PrrA that is involved specifically in early intracellular multiplication of Mycobacterium and is essential for its viability. Functions as a sensor protein kinase which is autophosphorylated at a histidine residue and transfers its phosphate group to the conserved aspartic acid residue in the regulatory domain of PrrA. In turn, PrrA binds to the upstream promoter regions of target genes including itself to positively regulate their expression. | 0.630 |
page 1 of 3