STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ML0842Conserved hypothetical protein; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. (411 aa)    
Predicted Functional Partners:
ML0596
Putative aminotransferase; Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.
  
  
 
0.908
trxB-2
Bifunctional thioredoxin reductase/thioredoxin; EC_number=EC 1.6.4.5; Previously sequenced and characterised: Mycobacterium leprae bifunctional thioredoxin reductase/thioredoxin [includes: thioredoxin reductase SW:TRXB_MYCLE (P46843) fasta scores: E(): 0, 100.0% in 458 aa. Contains Pfam match to entry PF00085 thiored, Thioredoxin. Contains Pfam match to entry PF00070 pyr_redox, Pyridine nucleotide-disulphide oxidoreductase. Contains PS00573 Pyridine nucleotide-disulphide oxidoreductases class-II active site. Contains PS00194 Thioredoxin family active site.
  
 
  0.907
metB
Cystathionine [gamma]-synthase; Catalyzes the formation of L-cystathionine from O-succinyl-L- homoserine (OSHS) and L-cysteine, via a gamma-replacement reaction. In the absence of thiol, catalyzes gamma-elimination to form 2- oxobutanoate, succinate and ammonia (By similarity).
     
 0.901
ML0597
Similar to M. tuberculosis Rv1465, conserved hypothetical protein, TR:O53156 (EMBL:AL123456) (162 aa); Fasta score E(): 0, 79.4% identity in 165 aa overlap. Similar to many hypothetical proteins and shows very weak similarity to proteins from N-fixation loci e.g. Anabaena azollae nifU, nitrogen fixation protein, SW:NIFU_ANAAZ (Q43885) (300 aa); Fasta score E(): 1.9, 24.4% identity in 90 aa overlap. Previously sequenced as TR:Q49683 (EMBL:U00013) (165 aa); Fasta score E(): 0, 100.0% identity in 165 aa overlap. Contains Pfam match to entry PF01883 DUF59, Domain of unknown function. Conta [...]
 
 
 0.884
ML0841
Major membrane protein I; Similar to Mycobacterium paratuberculosis 35 kDa protein TR:Q9RAJ4 (EMBL:AJ250887) (307 aa) fasta scores: E(): 0, 92.2% id in 307 aa and to Mycobacterium avium major membrane protein I mmpI SW:MMP1_MYCAV (Q48899) (307 aa) fasta scores: E(): 0, 89.6% id in 308 aa. Previously sequenced as SW:MMP1_MYCLE (P46841); To M.avium MmpI and Synechococcus PCC 7942 SrpI.
 
   
 0.856
ML0595
Similar to M. tuberculosis Rv1463, putative ABC transporter ATP-binding protein, TR:O53154 (EMBL:AL123456) (266 aa); Fasta score E(): 0, 85.8% identity in 267 aa overlap. Similar to many members of the ABC transporter family, including members found in chloroplast genomes e.g. Cyanophora paradoxa ycf16, probable ATP-dependent transporter, SW:ABCX_CYAPA (P48255) (259 aa); Fasta score E(): 0, 54.2% identity in 227 aa overlap. Previously sequenced as TR:Q49693 (EMBL:U00013) (260 aa); Fasta score E(): 0, 100.0% identity in 260 aa overlap. Contains Pfam match to entry PF00005 ABC_tran, ABC [...]
 
  
 0.854
ML0593
Similar to M. tuberculosis Rv1461, hypothetical protein, SW:YE61_MYCTU (O53152) (846 aa); Fasta score E(): 0, 54.3% identity in 920 aa overlap. N- and C-termini are similar to various bacterial hypothetical proteins e.g. Streptomyces coelicolor SCC22.07C, conserved hypothetical protein, TR:Q9XAD1 (EMBL:AL096839) (473 aa); Fasta score E(): 0, 45.5% identity in 853 aa overlap. Contains an intein from amino acids 202-587 inclusive. The intein is different to the one in the M. tuberculosis orthologue and at a different relative position. Previously sequenced as SW:YE61_MYCLE (Q49689) (869 [...]
 
 
 0.844
ML0594
Similar to M. tuberculosis Rv1462, conserved hypothetical protein, SW:YE62_MYCTU (O53153) (397 aa); Fasta score E(): 0, 80.4% identity in 392 aa overlap. Similar to many bacterial hypothetical proteins e.g. Streptomyces coelicolor SCC22.06C, conserved hypothetical protein, TR:Q9XAD2 (EMBL:AL096839) (394 aa); Fasta score E(): 0, 58.6% identity in 365 aa overlap. Previously sequenced as SW:YE62_MYCLE (Q49682) (392 aa); Fasta score E(): 0, 100.0% identity in 392 aa overlap. Contains Pfam match to entry PF01458 UPF0051, Uncharacterized protein family (UPF0051); Similar to to the C-terminal [...]
 
 
 0.812
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.