STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
lipBPutative lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (235 aa)    
Predicted Functional Partners:
lipA
Putative lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 0.999
gcvH
Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.
   
 0.955
ML0861
Putative dihydrolipoamide acyltransferase; Similar to Mycobacterium tuberculosis dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB or Rv2215 or MTCY190.26 SW:ODO2_MYCTU (Q10381) (553 aa) fasta scores: E(): 0, 81.8% id in 555 aa. Similar to Streptomyces seoulensis dihydrolipoamide acetyltransferase pdhB TR:Q9Z6I4 (EMBL:AF047034) (612 aa) fasta scores: E(): 0, 51.6% id in 614 aa and to many succinyltransferases e.g. Escherichia coli dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex sucB SW:ODO2_ECOLI (P07016) [...]
 
 
 0.869
fas
Fatty acid synthase; Identical to the previously sequenced Mycobacterium leprae putative type I fatty acid synthase TR:Q9X7E2 (EMBL:AL049478) (3076 aa); Fasta score E(): 0, 100.0% identity in 3076 aa overlap. Also highly similar to many other fatty acid synthases including: Mycobacterium tuberculosis Rv2524c TR:P95029 (EMBL:Z83863) (3069 aa); Fasta score E(): 0, 85.8% identity in 3081 aa overlap and Corynebacterium ammoniagenes fatty-acid synthase (EC 2.3.1.85) TR:Q59497 (EMBL:X87822) (3063 aa); Fasta score E(): 0, 44.3% identity in 3106 aa overlap. Contains Pfam match to entry PF00109 [...]
    
 0.825
ML0857
Putative membrane protein; Similar to Mycobacterium tuberculosis hypothetical 26.9 kDa protein Rv2219 or MTCY190.30 SW:YM19_MYCTU (Q10405) (250 aa) fasta scores: E(): 0, 80.8% id in 250 aa. Similar to Streptomyces coelicolor putative integral membrane protein SC3H12.04 TR:CAB90843 (EMBL:AL355740) (234 aa) fasta scores: E(): 1.2e-26, 39.6% id in 230 aa and to Streptomyces coelicolor putative integral membrane protein SC5F7.05 TR:Q9S2P0 (EMBL:AL096872) (234 aa) fasta scores: E(): 1.2e-26, 39.6% id in 230 aa. Previously sequenced as TR:O32963 (EMBL:Z98741). Contains hydrophobic, possible [...]
       0.819
ML0860
Conserved hypothetical protein; Similar to Mycobacterium tuberculosis hypothetical 31.7 kDa protein Rv2216 or MTCY190.27 SW:YM16_MYCTU (Q10403) (301 aa) fasta scores: E(): 0, 84.2% id in 297 aa. Similar to many hypothetical proteins from both bacteria and eukaryotes e.g. to Drosophila melanogaster CG8768 TR:Q9V6F9 (EMBL:AE003821) (297 aa) fasta scores: E(): 6.3e-26, 31.3% id in 304 aa. Previously sequenced as SW:YM16_MYCLE (O32960); Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily.
       0.766
ML0450
Putative pyridoxine biosynthesis protein; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family.
      
 0.753
ML0729
Conserved hypothetical protein; Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids.
      
 0.646
ML2355
Similar to several polyketide synthases e.g. Mycobacterium tuberculosis Rv2933 TR:P96202 (EMBL:Z83857) (2188 aa) fasta scores: E(): 0, 82.3% id in 2217 aa. Contains Pfam match to entry PF00109 ketoacyl-synt, Beta-ketoacyl synthase. Contains Pfam match to entry PF00107 adh_zinc, Zinc-binding dehydrogenases. Contains Pfam match to entry PF00698 Acyl_transf, Acyl transferase domain. Contains Pfam match to entry PF00550 pp-binding, Phosphopantetheine attachment site. Contains PS00012 Phosphopantetheine attachment site. Contains PS00133 Zinc carboxypeptidases. Contains PS00606 Beta-ketoacyl [...]
  
 0.636
ML0135
Similar to many polyketide synthases from M. tuberculosis e.g. N-terminus is similar to Rv2947c, pks15, probable polyketide synthase, TR:P96284 (EMBL:Z83858) (496 aa); Fasta score E(): 0, 90.5% identity in 485 aa overlap and the remainder is similar to Rv2946c, pks1, probable polyketide synthase, TR:P96285 (EMBL:Z83858) (1616 aa); Fasta score E(): 0, 82.5% identity in 1620 aa overlap. Similar to many others e.g. Streptomyces noursei NysC, nystatin biosynthesis polyketide synthase, TR:AAF71776 (EMBL:AF263912) (11096 aa); Fasta score E(): 0, 50.2% identity in 2161 aa overlap. Contains Pf [...]
  
 0.634
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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