STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Coexpression
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[Homology]
Score
murDUDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (490 aa)    
Predicted Functional Partners:
murC
UDP-N-acetyl-muramate-alanine ligase; Cell wall formation; Belongs to the MurCDEF family.
 
 
 0.999
murE
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
 
0.998
murG
Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.998
murF
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily.
 
  
0.995
mraY
phospho-N-acetylmuramoyl- pentapeptidetransferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
  
 0.993
murI
Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis.
 
  
 0.988
ML0916
Putative FtsQ-family protein; Essential cell division protein; Belongs to the FtsQ/DivIB family. FtsQ subfamily.
  
  
 0.975
ftsW
Putative cell division protein FtsW; Identical to the previously sequenced Mycobacterium leprae cell division protein, FtsW, TR:O69553 (EMBL:AL022602) (534 aa); Fasta score E(): 0, 99.8% identity in 534 aa overlap(EMBL:AL022602). Also highly similar many other FtsW-family proteins involved in cell wall formation e.g. from Mycobacterium tuberculosis FtsW-like protein SW:FTWH_MYCTU (SW:O06223) (524 aa); Fasta score E(): 0, 76.5% identity in 528 aa overlap(SW:O06223) and Escherichia coli FtsW SW:FTSW_ECOLI (SW:P16457) (414 aa); Fasta score E(): 3.6e-31, 37.0% identity in 370 aa overlap(SW [...]
  
 0.974
murA
UDP-N-acetylglucosamine-1- carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
 
   
 0.945
murB
UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation.
 
   
 0.938
Your Current Organism:
Mycobacterium leprae
NCBI taxonomy Id: 272631
Other names: M. leprae TN, Mycobacterium leprae TN, Mycobacterium leprae str. TN, Mycobacterium leprae strain TN
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